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Comment
. 2018 Dec 18;49(6):997-999.
doi: 10.1016/j.immuni.2018.12.007.

The Dendritic Cell Strikes Back

Christine Moussion  1 , Ira Mellman  2
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The Dendritic Cell Strikes Back

Christine Moussion et al. Immunity. .
Free article

Erratum in

  • The Dendritic Cell Strikes Back.
    Moussion C, Mellman I. Moussion C, et al. Immunity. 2019 Feb 19;50(2):533. doi: 10.1016/j.immuni.2019.01.022. Immunity. 2019. PMID: 30784580 No abstract available.

Abstract

The field of cancer immunotherapy and checkpoint blockade has focused largely on direct effects on T cells. In this issue of Immunity, Garris et al. (2018) show that the efficacy of anti-PD-1 therapy depends on a T-cell-dendritic-cell (DC) licensing loop fueled by IFN-γ and IL-12, thereby establishing a central role for DCs in promoting anti-cancer T cell immunity during checkpoint blockade.

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