Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2018 Dec 18;10(12):2000.
doi: 10.3390/nu10122000.

Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

Almudena Sánchez-Villegas  1   2 , Jacqueline Álvarez-Pérez  3   4 , Estefanía Toledo  5   6 , Jordi Salas-Salvadó  7   8   9   10 , Carolina Ortega-Azorín  11   12 , Maria Dolores Zomeño  13   14 , Jesús Vioque  15   16 , Jose Alfredo Martínez  17   18 , Dora Romaguera  19   20 , Jessica Pérez-López  21 , José López-Miranda  22   23 , Ramón Estruch  24   25 , Aurora Bueno-Cavanillas  26   27 , Fernando Arós  28   29   30 , Josep A Tur  31   32 , Francisco J Tinahones  33   34   35 , Oscar Lecea  36   37   38 , Vicente Martín  39   40 , M Ortega-Calvo  41   42 , Clotilde Vázquez  43   44 , Xavier Pintó  45   46 , Josep Vidal  47   48 , Lidia Daimiel  49 , Miguel Delgado-Rodríguez  50   51 , Pilar Matía  52 , Dolores Corella  53   54 , Andrés Díaz-López  55   56   57 , Nancy Babio  58   59   60 , Miguel Ángel Muñoz  61 , Montserrat Fitó  62   63 , Manoli García de la Hera  64   65 , Itziar Abete  66 , Antonio García-Rios  67   68 , Emilio Ros  69   70 , Miguel Ruíz-Canela  71   72 , Miguel Ángel Martínez-González  73   74   75 , Marisol Izquierdo  76 , Lluis Serra-Majem  77   78
Affiliations
Randomized Controlled Trial

Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

Almudena Sánchez-Villegas et al. Nutrients. .

Abstract

Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence.

Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms.

Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression.

Conclusion: In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.

Keywords: depression; docosahexaenoic acid; eicosapentaenoic acid; fish; omega-3.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Spline regression models. (A) Spline regression model of the odds ratio of depression according to fatty fish consumption (the dotted lines represent 95% CI). (B) Spline regression model of the odds ratio of depression according to LC ω-3 PUFA intake (the dotted lines represent 95% CI).
Figure 1
Figure 1
Spline regression models. (A) Spline regression model of the odds ratio of depression according to fatty fish consumption (the dotted lines represent 95% CI). (B) Spline regression model of the odds ratio of depression according to LC ω-3 PUFA intake (the dotted lines represent 95% CI).
See this image and copyright information in PMC

References

    1. Murray C.J., Vos T., Lozano R., Naghavi M., Flaxman A.D., Michaud C., Ezzati M., Shibuya K., Salomon J.A., Abdalla S., et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2197–2223. doi: 10.1016/S0140-6736(12)61689-4. - DOI - PubMed
    1. Mykletun A., Bjerkeset O., Overland S., Prince M., Dewey M., Stewart R. Levels of anxiety and depression as predictors of mortality: The HUNT study. Br. J. Psychiatry. 2009;195:118–125. doi: 10.1192/bjp.bp.108.054866. - DOI - PubMed
    1. Sarris J., Logan A.C., Akbaraly T.N., Paul Amminger G., Balanzá-Martínez V., Freeman M.P., Hibbeln J., Matsuoka Y., Mischoulon D., Mizoue T., et al. International Society for Nutritional Psychiatry Research consensus position statement: Nutritional medicine in modern psychiatry. World Psychiatry. 2015;14:370–371. doi: 10.1002/wps.20223. - DOI - PMC - PubMed
    1. Wysoczański T., Sokoła-Wysoczańska E., Pękala J., Lochyński S., Czyż K., Bodkowski R., Herbinger G., Patkowska-Sokoła B., Librowski T. Omega-3 Fatty Acids and their Role in Central Nervous System—A Review. Curr. Med. Chem. 2016;23:816–831. doi: 10.2174/0929867323666160122114439. - DOI - PubMed
    1. Kiecolt-Glaser J.K., Derry H.M., Fagundes C.P. Inflammation: Depression fans the flames and feasts on the heat. Am. J. Psychiatry. 2015;172:1075–1091. doi: 10.1176/appi.ajp.2015.15020152. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances