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Comment
. 2019 Jan 7;216(1):4-6.
doi: 10.1084/jem.20182059. Epub 2018 Dec 19.

Neutrophil: A mobile fertilizer

Lai Guan Ng  1
Affiliations
Comment

Neutrophil: A mobile fertilizer

Lai Guan Ng. J Exp Med. .

Abstract

In this issue of JEM, Lee et al. (https://doi.org/10.1084/jem.20181170) provide evidence to show that early influx of neutrophils into omentum represents a key mechanism in establishing the premetastatic niche for the subsequent implantation of ovarian cancer cells at this site.

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Figures

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Primary ovarian cancer induces the formation of the premetastatic niche by mobilizing neutrophils to the omentum through the PNAd+ blood vessels before the appearance of cancer cells. In response to cancer-derived factors, neutrophils are activated and release NETs. Consequently, these NETs promote dissemination of ovarian cancer cells to the omentum by trapping them at this site.
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