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. 2018 Nov 27:14:3259-3265.
doi: 10.2147/NDT.S186673. eCollection 2018.

Association of HLA alleles with autism

Arezou Sayad  1 , Mohammad Taghi Akbari  2 , Rezvan Noroozi  3 , Mir Davood Omrani  1   4 , Hidetoshi Inoko  5 , Mohammad Taheri  6 , Soudeh Ghafouri-Fard  1
Affiliations

Association of HLA alleles with autism

Arezou Sayad et al. Neuropsychiatr Dis Treat. .

Abstract

Background: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis.

Methods: Among them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls.

Results: After Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population.

Conclusion: Future studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis.

Keywords: HLA typing; autism; immune response.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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