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Weibel-Palade bodies are small storage granules found in endothelial cells located in the intima of the heart and blood vessels. They are found in arteries, capillaries, veins, and the endocardium but are notably absent in lymphatic vessels. These bodies primarily store 2 key molecules—P-selectin and von Willebrand factor (vWF)—which have important roles in inflammation and hemostasis.
Kalagara T, Moutsis T, Yang Y, Pappelbaum KI, Farken A, Cladder-Micus L, Vidal-Y-Sy S, John A, Bauer AT, Moerschbacher BM, Schneider SW, Gorzelanny C. The endothelial glycocalyx anchors von Willebrand factor fibers to the vascular endothelium. Blood Adv. 2018 Sep 25;2(18):2347-2357.
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Turner NA, Moake JL. Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings. PLoS One. 2015;10(10):e0140740.
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Nightingale TD, McCormack JJ, Grimes W, Robinson C, Lopes da Silva M, White IJ, Vaughan A, Cramer LP, Cutler DF. Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade bodies. J Thromb Haemost. 2018 Sep;16(9):1873-1886.
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Singh D, Natarajan A, Nand S, Mai HP. Genetics of Hypercoagulable and Hypocoagulable States. Neurosurg Clin N Am. 2018 Oct;29(4):493-501.
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