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Book

Aplasia Cutis Congenita

Jared Brackenrich  1 , Haitham M. Saleh  2 , Aleksandra Brown
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Aplasia Cutis Congenita

Jared Brackenrich et al.
Free Books & Documents

Excerpt

Aplasia cutis congenita (ACC) is a rare congenital skin defect involving focal or extensive absence of the epidermis, dermis, and, occasionally, subcutaneous tissue. The exact etiology remains unclear, with proposed mechanisms including impaired prenatal skin development. Initially reported by Cordon in 1767, ACC may present as solitary or multiple lesions on any body region, with 70% to 90% localized to the vertex of the scalp. Classification includes 6 subtypes, some associated with congenital dermatologic syndromes. Most lesions heal spontaneously. However, certain locations and clinical features warrant thorough evaluation to detect underlying soft tissue anomalies that may be life-threatening.

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Conflict of interest statement

Disclosure: Jared Brackenrich declares no relevant financial relationships with ineligible companies.

Disclosure: Haitham Saleh declares no relevant financial relationships with ineligible companies.

Disclosure: Aleksandra Brown declares no relevant financial relationships with ineligible companies.

References

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    1. Belkhou A, François C, Bennis Y, Duquennoy-Martinot V, Guerreschi P. [Aplasia cutis congenita: Update and management]. Ann Chir Plast Esthet. 2016 Oct;61(5):450-461. - PubMed
    1. Magliah T, Alghamdi F. Aplasia Cutis Congenita: A Case Report. Case Rep Dermatol. 2018 May-Aug;10(2):182-186. - PMC - PubMed
    1. Frieden IJ. Aplasia cutis congenita: a clinical review and proposal for classification. J Am Acad Dermatol. 1986 Apr;14(4):646-60. - PubMed
    1. Lonie S, Phua Y, Burge J. Technique for Management of Aplasia Cutis Congenita of the Scalp With a Skin Allograft. J Craniofac Surg. 2016 Jun;27(4):1049-50. - PubMed

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