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Book

Thyroid Nodule

Edgar A. Zamora  1 , Swapnil Khare  2 , Sebastiano Cassaro  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Thyroid Nodule

Edgar A. Zamora et al.
Free Books & Documents

Excerpt

The American Thyroid Association (ATA) defines the thyroid nodule as a discrete lesion within the thyroid gland. It is radiologically distinct from the surrounding thyroid parenchyma. Nodules may be solitary, multiple, cystic, or solid.

Nodules in the thyroid gland are a common entity and are detected in approximately 5% to 7% of the adult population by physical examination alone. However, autopsy data have shown a 50% prevalence of thyroid nodules larger than one centimeter in patients without previously diagnosed thyroid disease. Nodules are found with increasing frequency, likely due to the widespread use of modern imaging modalities, particularly ultrasound (US), but also computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET).

Although more than 90% of detected nodules are clinically insignificant benign lesions, thyroid nodules are clinically important as they may represent thyroid cancer in approximately 4.0% to 6.5% of cases.

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Conflict of interest statement

Disclosure: Edgar Zamora declares no relevant financial relationships with ineligible companies.

Disclosure: Swapnil Khare declares no relevant financial relationships with ineligible companies.

Disclosure: Sebastiano Cassaro declares no relevant financial relationships with ineligible companies.

References

    1. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016 Jan;26(1):1-133. - PMC - PubMed
    1. Pemayun TG. Current Diagnosis and Management of Thyroid Nodules. Acta Med Indones. 2016 Jul;48(3):247-257. - PubMed
    1. Bomeli SR, LeBeau SO, Ferris RL. Evaluation of a thyroid nodule. Otolaryngol Clin North Am. 2010 Apr;43(2):229-38, vii. - PMC - PubMed
    1. Durante C, Costante G, Lucisano G, Bruno R, Meringolo D, Paciaroni A, Puxeddu E, Torlontano M, Tumino S, Attard M, Lamartina L, Nicolucci A, Filetti S. The natural history of benign thyroid nodules. JAMA. 2015 Mar 03;313(9):926-35. - PubMed
    1. Popoveniuc G, Jonklaas J. Thyroid nodules. Med Clin North Am. 2012 Mar;96(2):329-49. - PMC - PubMed

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