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Editorial
. 2018 Dec 4;138(23):2662-2665.
doi: 10.1161/CIRCULATIONAHA.118.036771.

Is Inflammasome a Potential Target of Prophylaxis in Rheumatic Heart Disease?

Teneema Kuriakose  1 , Thirumala-Devi Kanneganti  1
Affiliations
Editorial

Is Inflammasome a Potential Target of Prophylaxis in Rheumatic Heart Disease?

Teneema Kuriakose et al. Circulation. .
No abstract available

Keywords: Editorials; IL-1β; acute rheumatic fever; group A streptococcus; hydroxychloroquine; inflammasomes; rheumatic heart disease.

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Figures

Figure 1:
Figure 1:. Possible role of inflammasomes in pathogenesis of Rheumatic Heart Disease (RHD).
Infection by Group A Streptococcus (GAS) activates the inflammasome leading to processing and release of IL-1β. IL-1β facilitates the expansion of GM-CSF-expressing Th1 CD4+ T cells. These cells traffic to the heart valve and the inflammatory cytokines secreted from these cells induce valvulitis, cardiac dysfunction and subsequent RHD in high-risk patients with acute rheumatic fever (ARF). Hydroxychloroquine (HCQ) limits the expansion of Th1 CD4+ T cells. HCQ could also have a possible function in limiting inflammasome activation.
See this image and copyright information in PMC

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References

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