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Review
. 2018 Nov 9;123(11):1199-1201.
doi: 10.1161/CIRCRESAHA.118.313884.

Beta1-Adrenergic Receptor Regulation Revisited

Susan F Steinberg  1
Affiliations
Review

Beta1-Adrenergic Receptor Regulation Revisited

Susan F Steinberg. Circ Res. .

Abstract

The actions and regulation of cardiomyocyte β1ARs differ in several respects from the properties described for the prototypical β2AR subtype; a mechanism to explain the unique properties of the β1AR subtype has never been obvious. This viewpoint summarizes recent studies that identify a novel signaling paradigm for the β1AR, implicating the N-terminus as a molecular determinant of β1AR responsiveness.

Keywords: apoptosis; arrestin; catecholamine; heart failure; immunoblotting.

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Figures

Figure 1:
Figure 1:
β1AR N-terminal processing (see text).
See this image and copyright information in PMC

References

    1. Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK. Crystal structure of the human β2-adrenergic G-protein-coupled receptor. Nature. 2007;450:383–387 - PubMed
    1. Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and heart failure in β1-adrenergic receptor transgenic mice Proc Natl Acad Sci USA. 1999;96:7059–7064 - PMC - PubMed
    1. Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ. Enhanced myocardial function in transgenic mice overexpressing the β2-adrenergic receptor. Science. 1994;264:582–586 - PubMed
    1. Singh K, Xiao L, Remondino A, Sawyer DB, Colucci WS. Adrenergic regulation of cardiac myocyte apoptosis. J Cell Physiol. 2001;189:257–265 - PubMed
    1. Rohrer DK, Desai KH, Jasper JR, Stevens ME, Regula DP, Barsh GS, Bernstein D, Kobilka BK. Targeted disruption of the mouse β1-adrenergic receptor gene: Developmental and cardiovascular effects. Proc Natl Acad Sci USA. 1996;93:7375–7380 - PMC - PubMed

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