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Review
. 2018 Nov 20;7(22):e010595.
doi: 10.1161/JAHA.118.010595.

Emerging Arrhythmic Risk of Autoimmune and Inflammatory Cardiac Channelopathies

Pietro Enea Lazzerini  1 , Pier Leopoldo Capecchi  1 , Nabil El-Sherif  2 , Franco Laghi-Pasini  1 , Mohamed Boutjdir  2   3
Affiliations
Review

Emerging Arrhythmic Risk of Autoimmune and Inflammatory Cardiac Channelopathies

Pietro Enea Lazzerini et al. J Am Heart Assoc. .
No abstract available

Keywords: antibody; arrhythmia (mechanisms); inflammation; ion channel.

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Figures

Figure 1
Figure 1
Classification of arrhythmogenic cardiac channelopathies. Besides the “classic” inherited forms of cardiac channelopathies related to genetic mutations, a wider spectrum of acquired forms includes not only drug‐induced, but also autoimmune and inflammatory/fever‐induced, cardiac channelopathies.
Figure 2
Figure 2
Cardiac channelopathies and arrhythmias: from the channel to the patient. In a structurally normal heart, both inherited (genetic defects) and acquired (drugs, autoantibodies, and inflammation/fever) factors can induce cardiac ion channel dysfunction, responsible for electrophysiological changes leading to specific electrocardiographic phenotypes and cardiac arrhythmias.
See this image and copyright information in PMC

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