Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Nov 20;7(22):e010595.
doi: 10.1161/JAHA.118.010595.

Emerging Arrhythmic Risk of Autoimmune and Inflammatory Cardiac Channelopathies

Pietro Enea Lazzerini  1 , Pier Leopoldo Capecchi  1 , Nabil El-Sherif  2 , Franco Laghi-Pasini  1 , Mohamed Boutjdir  2   3
Affiliations
Review

Emerging Arrhythmic Risk of Autoimmune and Inflammatory Cardiac Channelopathies

Pietro Enea Lazzerini et al. J Am Heart Assoc. .
No abstract available

Keywords: antibody; arrhythmia (mechanisms); inflammation; ion channel.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Classification of arrhythmogenic cardiac channelopathies. Besides the “classic” inherited forms of cardiac channelopathies related to genetic mutations, a wider spectrum of acquired forms includes not only drug‐induced, but also autoimmune and inflammatory/fever‐induced, cardiac channelopathies.
Figure 2
Figure 2
Cardiac channelopathies and arrhythmias: from the channel to the patient. In a structurally normal heart, both inherited (genetic defects) and acquired (drugs, autoantibodies, and inflammation/fever) factors can induce cardiac ion channel dysfunction, responsible for electrophysiological changes leading to specific electrocardiographic phenotypes and cardiac arrhythmias.
See this image and copyright information in PMC

References

    1. Al‐Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, Deal BJ, Dickfeld T, Field ME, Fonarow GC, Gillis AM, Hlatky MA, Granger CB, Hammill SC, Joglar JA, Kay GN, Matlock DD, Myerburg RJ, Page RL. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2017. Available at: https://www.ahajournals.org/doi/10.1161/CIR.0000000000000548. Accessed October 3, 2018. - DOI - PubMed
    1. Semsarian C, Ingles J. Molecular autopsy in victims of inherited arrhythmias. J Arrhythm. 2016;32:359–365. - PMC - PubMed
    1. El‐Sherif N, Boutjdir M, Turitto G. Sudden cardiac death in ischemic heart disease: pathophysiology and risk stratification. Card Electrophysiol Clin. 2017;9:681–691. - PubMed
    1. Cerrone M, Priori SG. Genetics of sudden death: focus on inherited channelopathies. Eur Heart J. 2011;32:2109–2118. - PubMed
    1. Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G, Tracy C. HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm. 2013;10:1932–1963. - PubMed

Publication types

MeSH terms