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Editorial
. 2018 Nov 13;138(20):2243-2246.
doi: 10.1161/CIRCULATIONAHA.118.036143.

Inflammation, Inflammasome Activation, and Atrial Fibrillation

David R Van Wagoner  1 , Mina K Chung  1   2
Affiliations
Editorial

Inflammation, Inflammasome Activation, and Atrial Fibrillation

David R Van Wagoner et al. Circulation. .
No abstract available

Keywords: C-reactive protein; Editorials; atrial fibrillation; inflammasomes; inflammation; interleukins.

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The NLRP3 receptor is activated in a 2 step process (priming and activation) by many different types of stimuli, ranging from activation of Toll like receptors (TLRs), the IL1 receptor (IL1-R), TNF-receptors (TNFR), and Gq-coupled that promote IP3 production. Endoplasmic reticulum stress associated with obesity, hypoxia and ischemia also activates NLRP3 receptors, resulting in increased IL-1β and IL-18 production. Protein and/or peptide aggregates elicit the unfolded protein response; this promotes autophagy and mitophagy, resulting in impaired mitochondrial function, and reactive oxygen species (ROS) production that increases spontaneous release of calcium from the sarcoplasmic reticulum, contributing to atrial ectopy that can initiate episodes of atrial fibrillation.
See this image and copyright information in PMC

Comment on

  • Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation.
    Yao C, Veleva T, Scott L Jr, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I Dr, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Müller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N. Yao C, et al. Circulation. 2018 Nov 13;138(20):2227-2242. doi: 10.1161/CIRCULATIONAHA.118.035202. Circulation. 2018. PMID: 29802206 Free PMC article.

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