Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based Genes, Environment, and Melanoma (GEM) Study

Jonathan A Miles¹, Irene Orlow², Peter A Kanetsky³, Li Luo⁴, Anne E Cust⁵, Bruce K Armstrong⁶, Anne Kricker⁷, Hoda Anton-Culver⁸, Stephen B Gruber⁹, Richard P Gallagher¹⁰, Roberto Zanetti¹¹, Stefano Rosso¹¹, Lidia Sacchetto¹², Terence Dwyer¹³, David C Gibbs¹⁴, Klaus J Busam¹⁵, Vikram Mavinkurve², David W Ollila¹⁶, Colin B Begg², Marianne Berwick⁴, Nancy E Thomas¹⁷; GEM Study Group

Collaborators, Affiliations

Collaborators

Affiliations

¹ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina, USA.
² Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
³ Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
⁴ Department of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA.
⁵ Sydney School of Public Health, The University of Sydney, Sydney, Australia; Melanoma Institute Australia, The University of Sydney, North Sydney, Australia.
⁶ School of Public and Global Health, The University of Western Australia, Perth, Australia.
⁷ Sydney School of Public Health, The University of Sydney, Sydney, Australia.
⁸ Department of Epidemiology, University of California, Irvine, California, USA.
⁹ Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
¹⁰ British Columbia Cancer and Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
¹¹ Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy.
¹² Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy; Politecnico di Torino, Turin, Italy.
¹³ George Institute for Global Health, Nuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, UK.
¹⁴ Department of Epidemiology, Emory University, Atlanta, Georgia, USA.
¹⁵ Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
¹⁶ Department of Surgery, University of North Carolina, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
¹⁷ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. Electronic address: nthomas@med.unc.edu.

PMID: 30571972
PMCID: PMC6535117
DOI: 10.1016/j.jid.2018.11.030

Multicenter Study

Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based Genes, Environment, and Melanoma (GEM) Study

Jonathan A Miles et al. J Invest Dermatol. 2019 Jun.

. 2019 Jun;139(6):1410-1412.

doi: 10.1016/j.jid.2018.11.030. Epub 2018 Dec 17.

Authors

Collaborators

Affiliations

¹ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina, USA.
² Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
³ Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
⁴ Department of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA.
⁵ Sydney School of Public Health, The University of Sydney, Sydney, Australia; Melanoma Institute Australia, The University of Sydney, North Sydney, Australia.
⁶ School of Public and Global Health, The University of Western Australia, Perth, Australia.
⁷ Sydney School of Public Health, The University of Sydney, Sydney, Australia.
⁸ Department of Epidemiology, University of California, Irvine, California, USA.
⁹ Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
¹⁰ British Columbia Cancer and Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
¹¹ Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy.
¹² Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy; Politecnico di Torino, Turin, Italy.
¹³ George Institute for Global Health, Nuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, UK.
¹⁴ Department of Epidemiology, Emory University, Atlanta, Georgia, USA.
¹⁵ Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
¹⁶ Department of Surgery, University of North Carolina, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
¹⁷ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. Electronic address: nthomas@med.unc.edu.

PMID: 30571972
PMCID: PMC6535117
DOI: 10.1016/j.jid.2018.11.030

No abstract available

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest: No potential conflicts of interest were disclosed.

Comment on

A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q.
Teerlink C, Farnham J, Allen-Brady K, Camp NJ, Thomas A, Leachman S, Cannon-Albright L. Teerlink C, et al. Hum Genet. 2012 Jan;131(1):77-85. doi: 10.1007/s00439-011-1048-z. Epub 2011 Jun 26. Hum Genet. 2012. PMID: 21706340

References

1. Begg CB, Hummer AJ, Mujumdar U, Armstrong BK, Kricker A, Marrett LD, et al. A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma. Int J Epidemiol 2006;35(3):756–64. - PubMed
1. Begg CB, Orlow I, Hummer AJ, Armstrong BK, Kricker A, Marrett LD, et al. Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample. J Natl Cancer Inst 2005;97(20):1507–15. - PubMed
1. Delaunay J, Martin L, Bressac-de Paillerets B, Duru G, Ingster O, Thomas L. Improvement of Genetic Testing for Cutaneous Melanoma in Countries With Low to Moderate Incidence: The Rule of 2 vs the Rule of 3. JAMA Dermatol 2017;153(11):1122–9. - PMC - PubMed
1. Kricker A, Armstrong BK, Goumas C, Thomas NE, From L, Busam K, et al. Survival for Patients With Single and Multiple Primary Melanomas: The Genes, Environment, and Melanoma Study. JAMA Dermatol 2013:1–7. - PMC - PubMed
1. Millikan RC, Hummer A, Begg C, Player J, de Cotret AR, Winkel S, et al. Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study. Carcinogenesis 2006;27(3):610–8. - PubMed

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Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based Genes, Environment, and Melanoma (GEM) Study

Collaborators

Affiliations

Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based Genes, Environment, and Melanoma (GEM) Study

Authors

Collaborators

Affiliations

Conflict of interest statement

Comment on

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Research Materials