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Meta-Analysis
. 2018 Dec;97(51):e13611.
doi: 10.1097/MD.0000000000013611.

Tea consumption is associated with decreased risk of oral cancer: A comprehensive and dose-response meta-analysis based on 14 case-control studies (MOOSE compliant)

Hao Zhou  1 , Weiwei Wu  1 , Fengqin Wang  1 , Huizhong Qi  2 , Zhigang Cheng  1
Affiliations
Meta-Analysis

Tea consumption is associated with decreased risk of oral cancer: A comprehensive and dose-response meta-analysis based on 14 case-control studies (MOOSE compliant)

Hao Zhou et al. Medicine (Baltimore). 2018 Dec.

Abstract

The associations of tea consumption with risk of oral cancer remain not clear. The present meta-analysis aims to clarify the real relationship between tea intake and the risk of oral cancer and quantifies the potential dose-response relationship between them.A Web search was performed within Pubmed, Embase, and Web of Science databases to identify potential studies that evaluated the relationship between tea consumption and the risk of oral cancer on Mar 21th, 2018 without language restriction. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and combined to evaluate the strength of associations. Dose-response analysis was performed to quantitate the relationship between tea intake and risk of oral cancer.Total 14 articles were included in the final analysis. The pooled OR for evaluating the risk of oral cancer and tea intake was 0.700 (95% CI = 0.609-0.805, P <.001). The linearity model of dose-response analysis indicated that with increased 1 cup daily, the risk of oral cancer decreased by 6.2% degree (OR = 0.938, 95% CI = 0.922-0.955, P <.001). Subgroup analysis indicated an inverse association between tea intake and the risk of oral cancer except subgroup analysis of black tea and American people.These results suggest tea intake provides protection against oral cancer carcinogenesis. Additionally, more large-scale pooling and high-quality studies are necessary for detecting the precise relationship between tea intake and oral cancer risk in the future.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
The flow diagram of the literature search, analysis, and selection of studies used in the current meta-analysis.
Figure 2
Figure 2
Forrest plot showing the relationship between tea intake and the risk of oral cancer.
Figure 3
Figure 3
Linear and non-linear dose–response relationships between the risk of oral cancer and dose (A), duration time (B) and concentration (C) of tea intake. For concentration of tea intake, 0, 1, 2, and 3 corresponding to nondrinking, low level, moderate level and high level, respectively.
Figure 4
Figure 4
Begg's funnel plot for studies included in the meta-analysis of the relationship between tea intake and oral risk.
Figure 5
Figure 5
Sensitivity analysis of pooled ORs in this meta-analysis. OR = odds ration.
See this image and copyright information in PMC

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