Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2018 Dec;97(51):e13759.
doi: 10.1097/MD.0000000000013759.

Oncological markers CA-125, CA 19-9 and endometriosis

Ludek Fiala  1   2   3 , Petr Bob  2   4 , Jiri Raboch  2
Affiliations
Observational Study

Oncological markers CA-125, CA 19-9 and endometriosis

Ludek Fiala et al. Medicine (Baltimore). 2018 Dec.

Abstract

The endometrium tissue is functionally androgen related which plays an important role in women's fertility regulation. In addition recent findings show that endometrium related pathology is closely linked to disrupted androgen biosynthesis and associated regulatory functions. These findings also suggest that androgens might play an important role in endometrium related cancer pathology with significant implications for treatment.Based on these findings, we have assessed 50 female outpatients with endometriosis and the clinical investigations were focused on biochemical serum analysis of DHEAS, oncological markers CA-125 and CA 19-9, estradiol, thyreothropic hormone, and prolactin.The results show significant Spearman correlations of CA-125 and CA 19-9 with dehydroepiandrosterone- DHEA-S (R = 0.52 resp. R = 0.49).This result represents 1st reported finding documenting androgen related increase of CA-125 and CA 19-9 levels as significant markers of endometrium pathology and it is possible to assume that these potential biomarkers could have clinical importance with respect to timely diagnosis.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest

Figures

Figure 1
Figure 1
Dependence of DHEA-S with CA-125 and CA-19-9. DHEA-S = dehydroepiandrosterone sulfate.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cloke B, Christian M. The role of androgens and the androgen receptor in cycling endometrium. Mol Cell Endocrinol 2012;358:166–75. - PubMed
    1. Simitsidellis I, Saunders PT, Gibson DA. Androgens and endometrium: new insights and new targets. Mol Cell Endocrinol 2018;465:48–60. - PubMed
    1. Gibson DA, et al. A role for steroid sulfatase in intracrine regulation of endometrial decidualisation. J Mol Endocrinol 2018;JME-18-0037. - PMC - PubMed
    1. Barry JA, Azizia MM, Hardiman PJ. Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update 2014;20:748–58. - PMC - PubMed
    1. Ito TE, Khalil EDA, Taffel M, et al. Magnetic resonance imaging correlation to intraoperative findings of deeply infiltrative endometriosis. Fertil Steril 2017;107:e11–2. - PubMed

Publication types