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Randomized Controlled Trial
. 2018 Dec 20;18(1):194.
doi: 10.1186/s12871-018-0659-5.

Tramadol for the treatment of catheter-related bladder discomfort: a randomized controlled trial

Shuying Li  1 , Liping Song  1 , Yushan Ma  2 , Xuemei Lin  1
Affiliations
Randomized Controlled Trial

Tramadol for the treatment of catheter-related bladder discomfort: a randomized controlled trial

Shuying Li et al. BMC Anesthesiol. .

Abstract

Background: Intra-operative urinary catheterization frequently causes postoperative catheter related bladder discomfort (CRBD) during recovery. We conducted this study to evaluate the efficacy of tramadol, which with muscarinic receptor antagonist property, as a treatment for CRBD.

Methods: Ninety patients who underwent elective gynecological surgery and complained of CRBD in the (PACU) were randomized into three groups of 30 each. Group A received normal saline, group B 1 mg/kg tramadol, and group C 1.5 mg/kg tramadol. The medication was administered from the Murphy's dropper with a slow drip, and the severity of CRBD (none, mild, moderate, and severe) and postoperative pain were assessed after 0, 0.5, 1, 2 and 6 h.

Results: The severity of CRBD was reduced in group C compared with that in groups A and B at 1 h, and in groups C and B compared with that in group A at 2 h. The incidence of CRBD was reduced in group C compared with that in groups A and B at 2 h, and in group C compared with that in group A at 6 h. The visual analog scale (VAS) was reduced in group C compared with that in groups A and B at all time intervals. No differences in adverse effects were observed.

Conclusions: Tramadol 1.5 mg/kg was more effective than tramadol 1 mg/kg in treating CRBD and reducing postoperative pain, without significant side effects.

Trial registration: ChiCTR1800016390 . Registered on 30 May 2018.

Keywords: Catheter-related bladder discomfort; Tramadol; Treatment; VAS.

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Conflict of interest statement

Ethics approval and consent to participate

Ethical approval was obtained from China Ethics Committee of Registering Clinical Trials (ChiECRCT-20,180,059), address: West China Hospital, Sichuan University, NO. 37, Guo Xue Xiang, Chengdu, Sichuan, China. The trial was registered in the Chinese Clinical Trial Registry (ChiCTR1800016390, date of registration: 2018-5-30) prior to patient enrollment. Written informed consent was abtained from all patients.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Postoperative pain among the three groups
Fig. 2
Fig. 2
The adverse effects among the three groups
See this image and copyright information in PMC

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