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Comment
. 2019 Jan;68(1):15-17.
doi: 10.2337/dbi18-0045.

Glucagon-Like Peptide 1 in the Brain: Where Is It Coming From, Where Is It Going?

Derek Daniels  1   2 , Elizabeth G Mietlicki-Baase  2   3
Affiliations
Comment

Glucagon-Like Peptide 1 in the Brain: Where Is It Coming From, Where Is It Going?

Derek Daniels et al. Diabetes. 2019 Jan.
No abstract available

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Figures

Figure 1
Figure 1
GLP-1 interactions with the brain. GLP-1–producing cells (yellow circles) are found in areas including the ileum, olfactory bulb, and hindbrain. GLP-1–responsive structures in the brain are far more distributed and include structures behind (blue) and outside of (red) the blood-brain barrier, a subset of which are represented in this schematic. Knowing which source of GLP-1 acts on which of the responsive structures is important in order to understand the role of endogenous GLP-1 in the control of the diverse effects of GLP-1; question marks highlight the lack of detail in current knowledge about the sources of GLP-1 to these and other GLP-1–responsive sites. The article by Holt et al. (7) offers an important step toward this understanding. AP, area postrema; Arc, arcuate hypothalamic nucleus; IO, inferior olive; IP, interpeduncular nucleus; LH, lateral hypothalamus; LS, lateral septum; OVLT, organum vasculosum of the lamina terminalis; PDTg, posterodorsal tegmental nucleus; PVN, paraventricular hypothalamic nucleus; SCN, suprachiasmatic nucleus; SFO, subfornical organ; SON, supraoptic nucleus; VTA, ventral tegmental area.
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References

    1. Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007;87:1409–1439 - PubMed
    1. McKay NJ, Kanoski SE, Hayes MR, Daniels D. Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. Am J Physiol Regul Integr Comp Physiol 2011;301:R1755–R1764 - PMC - PubMed
    1. Sørensen G, Reddy IA, Weikop P, et al. The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice. Physiol Behav 2015;149:262–268 - PMC - PubMed
    1. Schmidt HD, Mietlicki-Baase EG, Ige KY, et al. Glucagon-like peptide-1 receptor activation in the ventral tegmental area decreases the reinforcing efficacy of cocaine. Neuropsychopharmacology 2016;41:1917–1928 - PMC - PubMed
    1. Trapp S, Richards JE. The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant? Curr Opin Pharmacol 2013;13:964–969 - PMC - PubMed

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