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. 2018 Dec 13;379(24):2377-2379.
doi: 10.1056/NEJMc1800098.

Neurodevelopment in Infants Exposed to Zika Virus In Utero

M Elisabeth Lopes Moreira  1 , Karin Nielsen-Saines  2 , Patricia Brasil  1 , Tara Kerin  3 , Luana Damasceno  1 , Marcos Pone  1 , Liege M A Carvalho  1 , Sheila M Pone  1 , Zilton Vasconcelos  1 , Ieda P Ribeiro  1 , Andrea A Zin  1 , Irena Tsui  3 , Kristina Adachi  3 , Stephanie L Gaw  4 , Umme-Aiman Halai  3 , Tania S Salles  1 , Denise C da Cunha  1 , Myrna C Bonaldo  1 , Claudia Raja Gabaglia  5 , Leticia Guida  1 , Jociele Malacarne  1 , Roozemerie P Costa  1 , S Clair Gomes Jr  1 , A Beatriz Reis  1 , Fernanda V M Soares  1 , Renata H Hasue  6 , Carolina Y P Aizawa  6 , Fernanda F Genovesi  6 , Mitsue Aibe  1 , Christa Einspieler  7 , Peter B Marschik  7 , J Paulo Pereira Jr  1 , Elyzabeth A Portari  1 , Carla Janzen  3 , James D Cherry  3
Affiliations

Neurodevelopment in Infants Exposed to Zika Virus In Utero

M Elisabeth Lopes Moreira et al. N Engl J Med. .
No abstract available

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Figures

Figure 1.
Figure 1.. Individual Scores on the Bayley-III Scales at 12 to 18 Months of Age, According to Neuroimaging Results.
Shown are the scores for cognitive, language, and motor functions on the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III). Standard scores on the Bayley-III scales range from 55 to 145, with higher scores indicating more advanced development; the mean (±SD) score is 100±15, and a score of less than 85 indicates a developmental delay and a score less than 70 indicates severe developmental delay. The scores of 94 children who had in utero exposure to Zika virus are indicated by circles. The solid horizontal lines represent median values, and the I bars interquartile ranges.
See this image and copyright information in PMC

References

    1. Brasil P, Pereira JP Jr, Moreira ME, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med 2016;375:2321–34. - PMC - PubMed
    1. Zin AA, Tsui I, Rossetto J, et al. Screening criteria for ophthalmic manifestations of congenital Zika virus infection. JAMA Pediatr 2017;171:847–54. - PMC - PubMed
    1. Bayley N Bayley scales of infant and toddler development: administration manual 3rd ed. San Antonio, TX: Harcourt Assessment, 2006.
    1. Madaschi V, Macedo EC, Mecca TP, Pauls CS. Bayley-III scales of infant and toddler development: transcultural adaptation and psychometric properties. Paidéia (Ribeirão Preto) 2016; 26:189–97.
    1. Reynolds MR, Jones AM, Petersen EE, et al. Vital signs: update on Zika virus–associated birth defects and evaluation of all U.S. infants with congenital Zika virus exposure — U.S. Zika Pregnancy Registry, 2016. MMWR Morb Mortal Wkly Rep 2017; 66:366–73. - PMC - PubMed