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Review
. 2019 Apr;50(2):116-121.
doi: 10.1055/s-0038-1676514. Epub 2018 Dec 21.

Muscle-Specific Kinase Autoimmune Myasthenia Gravis: Report of a Pediatric Case and Literature Review

Thouraya Ben Younes  1 , Hanene Benrhouma  1   2 , Hedia Klaa  1   2 , Rania Ben Aoun  1   2 , Aida Rouissi  1   2 , Melika Ben Ahmed  2   3 , Ichraf Kraoua  1   2 , Ilhem Ben Youssef-Turki  1   2
Affiliations
Review

Muscle-Specific Kinase Autoimmune Myasthenia Gravis: Report of a Pediatric Case and Literature Review

Thouraya Ben Younes et al. Neuropediatrics. 2019 Apr.

Abstract

Myasthenia gravis (MG) with antibodies to the muscle-specific tyrosine kinase (MuSK-MG) receptor is a rare entity. It represents 5 to 8% of all MG patients. Few pediatric cases were reported. Clinical presentation is often atypical. It is characterized by predominant involvement of cranial, bulbar, and axial muscles and early respiratory crises. Myokymia and fasciculation are suggestive of MuSK-MG. The clinical course of patients with MuSK-MG is worse than other types of MG. Responses to standard therapies are variable. We report clinical, neurophysiological, serological, and outcome profile of a Tunisian child with MuSK-MG.

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Conflict of interest statement

None declared.