Patient re-contact after revision of genomic test results: points to consider-a statement of the American College of Medical Genetics and Genomics (ACMG)

Affiliations

¹ Division of Genetics, Department of Medicine, NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA. kld9001@nyp.org.
² University of South Carolina School of Medicine Greenville and Greenville Health System, Greenville, SC, USA.
³ Regional Precision Tracking and Genetics Department, Kaiser Permanente Northern California, Oakland, CA, USA.
⁴ Pediatric Clinical Genetics, Columbia University Medical Center, New York, USA.
⁵ Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
⁶ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
⁷ Center for Personalized Genetic Healthcare, Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
⁸ Division of Genetics, Department of Pediatrics, Boston Medical Center, Boston, MA, USA.
⁹ Division of Genetics and Genomics and the Manton Center for Orphan Disease Research, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
¹⁰ Genetic Alliance, Washington, DC, USA.
¹¹ Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Free article

Karen L David et al. Genet Med. 2019 Apr.

Free article

. 2019 Apr;21(4):769-771.

doi: 10.1038/s41436-018-0391-z. Epub 2018 Dec 22.

¹ Division of Genetics, Department of Medicine, NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA. kld9001@nyp.org.
² University of South Carolina School of Medicine Greenville and Greenville Health System, Greenville, SC, USA.
³ Regional Precision Tracking and Genetics Department, Kaiser Permanente Northern California, Oakland, CA, USA.
⁴ Pediatric Clinical Genetics, Columbia University Medical Center, New York, USA.
⁵ Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
⁶ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
⁷ Center for Personalized Genetic Healthcare, Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
⁸ Division of Genetics, Department of Pediatrics, Boston Medical Center, Boston, MA, USA.
⁹ Division of Genetics and Genomics and the Manton Center for Orphan Disease Research, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
¹⁰ Genetic Alliance, Washington, DC, USA.
¹¹ Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

No abstract available

Keywords: clinical genetics; duty to re-contact; medical ethics; reinterpretation of genomic results; variant reclassification.

Comment in

Response to Knoppers et al.
David KL, Best RG, Brenman LM, Bush L, Deignan J, Flannery D, Hoffman JD, Holm I, Miller DT, O'Leary J, Pyeritz RE. David KL, et al. Genet Med. 2019 Oct;21(10):2403. doi: 10.1038/s41436-019-0496-z. Epub 2019 Apr 11. Genet Med. 2019. PMID: 30971833 No abstract available.
Letter: Relearning the 3 R's? Reinterpretation, recontact, and return of genetic variants.
Knoppers BM, Thorogood A, Zawati MH. Knoppers BM, et al. Genet Med. 2019 Oct;21(10):2401-2402. doi: 10.1038/s41436-019-0494-1. Epub 2019 Apr 11. Genet Med. 2019. PMID: 30971835 No abstract available.