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. 2019 Apr;143(4):1633-1635.
doi: 10.1016/j.jaci.2018.11.037. Epub 2018 Dec 20.

Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults

Amber Dahlin  1 , Joanne E Sordillo  2 , John Ziniti  1 , Carlos Iribarren  3 , Meng Lu  3 , Scott T Weiss  4 , Kelan G Tantisira  4 , Quan Lu  5 , Mengyuan Kan  6 , Blanca E Himes  6 , Eric Jorgenson  3 , Ann Chen Wu  7
Affiliations

Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults

Amber Dahlin et al. J Allergy Clin Immunol. 2019 Apr.

Abstract

In this large, multi-ethnic GWAS of asthma, we identified novel associations with potential functional relevance for asthma susceptibility in older adults of diverse racial backgrounds.

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Figures

Figure 1.
Figure 1.. Discovery GWAS Results for GERA Populations.
A. Manhattan plots for each GWAS are provided by racial/ethnic group, with chromosomal positions along the abscissa while –log(p-value) is shown on the ordinate axis. Horizontal lines indicate significance thresholds for genome-wide (black line) and suggestive genome-wide associations (dashed line), respectively. B. Q-Q plot of results for each GWAS. For all populations, λgc values were 1.0–1.004.
See this image and copyright information in PMC

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