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Review
. 2019 Feb:56:100-106.
doi: 10.1016/j.coi.2018.11.003. Epub 2018 Dec 19.

Cellular pathways in the development of human and murine innate lymphoid cells

Steven D Scoville  1 , Aharon G Freud  2 , Michael A Caligiuri  3
Affiliations
Review

Cellular pathways in the development of human and murine innate lymphoid cells

Steven D Scoville et al. Curr Opin Immunol. 2019 Feb.

Abstract

Innate lymphoid cells (ILCs) are critical to effective immune surveillance against pathogens, have malignant counterparts, and contribute to disease. Thus, it is important to understand ILC development. All ILCs are derived from the common lymphoid progenitor cell; however, the exact mechanisms and signals that initiate their divergence from T cells, B cells and one and other are incompletely understood. Evidence now supports a stepwise developmental process that includes distinct cellular intermediates, progressively narrowed differentiation, and some plasticity. While the current models of human and murine ILC development share many similarities, they also include some distinct differences. Together these findings have established a working dynamic model of ILC development.

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Figures

Figure 1.
Figure 1.
Current pathways of murine ILC development
Figure 2.
Figure 2.
Current pathways of human ILC development
See this image and copyright information in PMC

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