Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan;122(1):e3-e5.
doi: 10.1016/j.bja.2018.09.014. Epub 2018 Oct 23.

Is malignant hyperthermia associated with hyperglycaemia?

F Altamirano  1 , S Riazi  2 , C A Ibarra Moreno  2 , N Kraeva  2 , A Uryash  3 , P D Allen  4 , J A Adams  3 , J R Lopez  5
Affiliations

Is malignant hyperthermia associated with hyperglycaemia?

F Altamirano et al. Br J Anaesth. 2019 Jan.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig 1
Fig 1
Impaired glucose homeostasis in malignant hyperthermia susceptible (MHS) individuals. (A) Retrospective study of 356 MHS patients showed increased blood glucose or hyperglycaemia in 42% of the patients. Please note the elevated values of blood glucose (fasting and random) and increased glycosylated haemoglobin (HbA1c) in patients with higher contracture response to caffeine and halothane. (B) Glucose tolerance test in MHS and MH normal (MHN) mice (n=5 per group). Mice were fasted overnight and glucose (2 g kg−1) was given by gastric gavage. Glucose was measured at the indicated times. Insert: glucose area under the curve (AUC). Dantrolene (2.0 mg kg−1 i.p.) pretreatment was given for 3 days. ***P<0.001, one-way analysis of variance (ANOVA)-Tukey. (C) Akt phosphorylation (Ser473) upon insulin (100 nM) stimulation determined by western blot in MHN and MHS myotubes (n=3 cultures for each genotype). ***P<0.001, one-way ANOVA-Dunnett compared with each control without stimulation (time point 0). Values are expressed as mean (standard deviation). Dantro, dantrolene.
See this image and copyright information in PMC

References

    1. Rosenberg H., Pollock N., Schiemann A., Bulger T., Stowell K. Malignant hyperthermia: a review. Orphanet J Rare Dis. 2015;10:93. - PMC - PubMed
    1. Jurkat-Rott K., Lerche H., Lehmann-Horn F. Skeletal muscle channelopathies. J Neurol. 2002;249:1493–1502. - PubMed
    1. Yang T., Allen P.D., Pessah I.N., Lopez J.R. Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutations. J Biol Chem. 2007;282:37471–37478. - PubMed
    1. Yang T., Esteve E., Pessah I.N., Molinski T.F., Allen P.D., Lopez J.R. Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SR. Am J Physiol Cell Physiol. 2007;292:C1591–C1598. - PubMed
    1. Yang T., Riehl J., Esteve E. Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology. 2006;105:1164–1175. - PubMed