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Comment
. 2019 Feb;25(2):70-72.
doi: 10.1016/j.molmed.2018.12.001. Epub 2018 Dec 20.

TNFα-Driven Astrocyte Purinergic Signaling during Epileptogenesis

Peter Bedner  1 , Christian Steinhäuser  2
Affiliations
Comment

TNFα-Driven Astrocyte Purinergic Signaling during Epileptogenesis

Peter Bedner et al. Trends Mol Med. 2019 Feb.

Abstract

The etiology of temporal lobe epilepsy is unclear, but proinflammatory molecules and disturbed neuron-glia communications are emerging as potential causers. A recent study (Nikolic et al. Glia 2018; https://doi.org/10.1002/glia.23519) revealed that pathologically elevated tumor necrosis factor α contributes to epileptogenesis, by boosting hyperexcitation through an autocrine mechanism involving purinergic signaling, astrocyte glutamate release, and modulation of neuronal transmitter release.

Keywords: P2Y1 receptor; TNFα; astrocyte; epilepsy; gliotransmission.

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