Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018;13(4):293-298.
doi: 10.5114/pg.2018.79808. Epub 2018 Dec 11.

The relationship between 174 G/C and -572 G/C of IL-6 gene polymorphisms and susceptibility of celiac disease in the Iranian population

Zeinab Barartabar  1 , Abdolrahim Nikzamir  1 , Majid Sirati-Sabet  1 , Elham Aghamohammadi  2 , Vahid Chaleshi  2 , Mohammad Rostami Nejad  2 , Hamid Asadzadeh-Aghdaei  3 , Mohammad Reza Zali  2
Affiliations

The relationship between 174 G/C and -572 G/C of IL-6 gene polymorphisms and susceptibility of celiac disease in the Iranian population

Zeinab Barartabar et al. Prz Gastroenterol. 2018.

Abstract

Introduction: Celiac disease (CD) is a chronic inflammatory intestinal disorder. Different immunological factors, including inflammatory cytokines, may play an important role in disease susceptibility.

Aim: To investigate the relationship between -174G/C and -572G/C gene polymorphisms and the serum level of interleukin 6 (IL-6) and susceptibility to CD in the Iranian population.

Material and methods: In this case-control study blood samples were collected of 105 patients with CD and 106 healthy subjects randomly in 2016 and evaluated by polymerase chain reaction-restriction fragments length polymorphism (PCR-RFLP) method. A sequence was also used to confirm the results of both polymorphisms. The IL-6 concentration was measured using ELISA.

Results: The results showed a significant relationship between polymorphism -572G in CD patients when compared with control subjects by genotype (p = 0.001) and alleles (p = 0.022), respectively. There was no significant relationship between polymorphism 174G and frequency of genotype, but an association of this polymorphism with the frequency of alleles (p = 0.034), age (p = 0.001), and body mass index (p = 0.003) was seen. The serum level of interleukin-6 was significantly associated only with rs1800796 (p < 0.001).

Conclusions: The results confirm previous studies in different parts of the world and indicate that IL-6 (572G/C) polymorphism may play a role in susceptibility to CD in the Iranian population.

Keywords: IL-6 gene polymorphism; autoimmune and inflammatory reaction; celiac disease; polymerase chain reaction-restriction fragments length polymorphism.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Sequence of rs1800795
Figure 2
Figure 2
Sequence of rs1800796
Figure 3
Figure 3
Relationship between serum levels in CD patients and healthy subjects
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997;3:797–801. - PubMed
    1. Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the united states: a large multicenter study. Arch Inter Med. 2003;163:286–92. - PubMed
    1. Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harbor Perspect Biol. 2014;6:a016295. - PMC - PubMed
    1. Rincon M. Interleukin-6: from an inflammatory marker to a target for inflammatory diseases. Trends Immunol. 2012;33:571–7. - PubMed
    1. Clot F, Babron MC. Genetics of celiac disease. Mol Genet Metabol. 2000;71:76–80. - PubMed