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. 2018 Dec 7:8:424.
doi: 10.3389/fcimb.2018.00424. eCollection 2018.

MDAD: A Special Resource for Microbe-Drug Associations

Ya-Zhou Sun  1 , De-Hong Zhang  2 , Shu-Bin Cai  1 , Zhong Ming  1 , Jian-Qiang Li  1 , Xing Chen  2
Affiliations

MDAD: A Special Resource for Microbe-Drug Associations

Ya-Zhou Sun et al. Front Cell Infect Microbiol. .

Abstract

The human-associated microbiota is diverse and complex. It takes an essential role in human health and behavior and is closely related to the occurrence and development of disease. Although the diversity and distribution of microbial communities have been widely studied, little is known about the function and dynamics of microbes in the human body or the complex mechanisms of interaction between them and drugs, which are important for drug discovery and design. A high-quality comprehensive microbe and drug association database will be extremely beneficial to explore the relationship between them. In this article, we developed the Microbe-Drug Association Database (MDAD), a collection of clinically or experimentally supported associations between microbes and drugs, collecting 5,055 entries that include 1,388 drugs and 180 microbes from multiple drug databases and related publications. Moreover, we provided detailed annotations for each record, including the molecular form of drugs or hyperlinks from DrugBank, microbe target information from Uniprot and the original reference links. We hope MDAD will be a useful resource for deeper understanding of microbe and drug interactions and will also be beneficial to drug design, disease therapy and human health.

Keywords: database; drug; drug discovery; drug target; microbe.

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Figures

Figure 1
Figure 1
The flowchart of MDAD construction. The flowchart shows the process of data processing and information integration.
Figure 2
Figure 2
The distribution of references included in MDAD by time of publication.
Figure 3
Figure 3
Diagrammatic representation of (A) topmost drugs in MDAD, (B) topmost microorganisms in MDAD.
Figure 4
Figure 4
The MDAD user interface showing the browse page.
Figure 5
Figure 5
The network map of associations between top 10 drugs and related microbes.
See this image and copyright information in PMC

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