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. 2018 Dec 14:4:737-745.
doi: 10.1016/j.trci.2018.10.010. eCollection 2018.

The SCD-Well randomized controlled trial: Effects of a mindfulness-based intervention versus health education on mental health in patients with subjective cognitive decline (SCD)

Natalie L Marchant  1 , Thorsten Barnhofer  2 , Olga M Klimecki  3 , Géraldine Poisnel  4 , Antoine Lutz  5 , Eider Arenaza-Urquijo  4 , Fabienne Collette  6 , Miranka Wirth  7   8 , Ann-Katrin Schild  9 , Nina Coll-Padrós  10 , Leslie Reyrolle  11 , Deborah Horney  1 , Pierre Krolak-Salmon  12 , José Luis Molinuevo  10 , Zuzana Walker  1   13 , Aline Maillard  14   15 , Eric Frison  14   15 , Frank Jessen  9   16 , Gael Chételat  4 ; SCD-WELL Medit-Ageing Research Group
Collaborators, Affiliations

The SCD-Well randomized controlled trial: Effects of a mindfulness-based intervention versus health education on mental health in patients with subjective cognitive decline (SCD)

Natalie L Marchant et al. Alzheimers Dement (N Y). .

Abstract

Introduction: Subjectively experienced cognitive decline in older adults is an indicator of increased risk for dementia and is also associated with increased levels of anxiety symptoms. As anxiety is itself emerging as a risk factor for cognitive decline and dementia, the primary question of the present study is whether an 8-week mindfulness-based intervention can significantly reduce anxiety symptoms in patients with subjective cognitive decline (SCD). The secondary questions pertain to whether such changes extend to other domains of psychological, social, and biological functioning (including cognition, self-regulation, lifestyle, well-being and quality of life, sleep, and selected blood-based biomarkers) associated with mental health, older age, and risk for dementia.

Methods: SCD-Well is a multicenter, observer-blinded, randomized, controlled, superiority trial, which is part of the Horizon 2020 European Union-funded "Medit-Ageing" project. SCD-Well compares an 8-week mindfulness- and compassion-based intervention specifically adapted for older adults with SCD with a validated 8-week health education program. Participants were recruited from memory clinics in four European sites (Cologne, Germany; London, United Kingdom; Barcelona, Spain; and Lyon, France) and randomized with a 1:1 allocation, stratified by site.

Results: The primary outcome, change in anxiety symptoms, and secondary outcomes reflecting psychological, cognitive, social, and biological functioning are assessed at baseline, postintervention, and 4 months after the end of the intervention.

Discussion: The study will provide evidence on whether a mindfulness-based intervention can effect changes in anxiety and other risk factors for cognitive decline and dementia in older adults with SCD and will inform the establishment of intervention strategies targeted at improving mental health in older adults.

Keywords: Alzheimer's disease; Anxiety; Cognition; Compassion; Dementia; Emotion; Medit-Ageing; Meditation; Mindfulness; Psychoeducation; Silver Santé Study; Subjective cognitive decline.

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References

    1. Prince M., Wimo A., Guerchet M., Ali G.C., Wu Y.T., Prina M. Alzheimer’s Disease International (ADI); 2015. World Alzheimer Report 2015—the Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends. London.
    1. Chetelat G., Villemagne V.L., Bourgeat P., Pike K.E., Jones G., Ames D. Relationship between atrophy and β-amyloid deposition in Alzheimer disease. Ann Neurol. 2010;67:317–324. - PubMed
    1. Carter S.F., Scholl M., Almkvist O., Wall A., Engler H., Langstrom B. Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: A multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG. J Nucl Med. 2012;53:37–46. - PubMed
    1. Livingston G., Sommerlad A., Orgeta V., Costafreda S.G., Huntley J., Ames D. Dementia prevention, intervention, and care. Lancet. 2017;390:2673–2734. - PubMed
    1. Norton S., Matthews F.E., Barnes D.E., Yaffe K., Brayne C. Potential for primary prevention of Alzheimer's disease: An analysis of population-based data. Lancet Neurol. 2014;13:788–794. - PubMed