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. 2018 Dec 25;19(12):3511-3515.
doi: 10.31557/APJCP.2018.19.12.3511.

Enzymatic Antioxidant and Lipid Peroxidation Evaluation in the Newly Diagnosed Breast Cancer Patients in Iran

Parisa Kangari  1   2 , Tahereh Zarnoosheh Farahany, Ali Golchin, Somayeh Ebadollahzadeh, Arash Salmaninejad, Soltan Ali Mahboob, Alireza Nourazarian
Affiliations

Enzymatic Antioxidant and Lipid Peroxidation Evaluation in the Newly Diagnosed Breast Cancer Patients in Iran

Parisa Kangari et al. Asian Pac J Cancer Prev. .

Abstract

Background: Breast cancer is caused by breast tissue malignant cells and it has become one of the main medical concerns with a socio-economic significance especially for women. Among the multiple factors involved in the initiation, progression, and invasion of breast cancer, oxidative stress plays an important role. Antioxidant status, lipid peroxidation, and oxidative stress in newly diagnosed breast cancer patients were determined to find a defined pattern of oxidative stress in these patients. Methods: The malondialdehyde (MDA) levels (as an indicator of lipid peroxidation), glutathione peroxidase (GPX), and superoxide dismutase (SOD) activities of newly diagnosed breast cancer patients (n=38) and controls (n=38) were assessed using blood samples. Results: MDA level and SOD activity were significantly higher in the breast cancer patients compared to the healthy subjects group (p<0.05). Compared to the healthy group, GPX activity decreased significantly in patients group (p<0.05). Conclusions: High lipid peroxidation is an important risk factor for breast cancer and the increased levels of superoxide anion in breast cancer cells may be a reason for the induction of SOD activity. Nevertheless, oxidative stress is an important factor in development and progression of breast cancer. Further studies on it can lead to a more helpful approach to management of breast cancer.

Keywords: Breast cancer; lipid peroxidation; oxidative stress; superoxide dismutase; glutathione peroxidase.

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Figures

Figure 1
Figure 1
Study Design which Shows the Summary of the Study Protocol
Figure 2
Figure 2
Extent of Lipid Peroxidation (MDA) in Serum of Patients and Controls. The bar diagram represents level of MDA in controls and cases as mean ±SE of three individual experiments done in triplicates
Figure 3
Figure 3
a) SOD activity, b) GPX activity, in patients and controls. The bar diagram represents activity of SOD and GPX in controls and cases as mean ±SE of three individual experiments done in triplicates
See this image and copyright information in PMC

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