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Review
. 2018 Oct 16;16(4 Suppl):e84784.
doi: 10.5812/ijem.84784. eCollection 2018 Oct.

Diabetes Mellitus: Findings from 20 Years of the Tehran Lipid and Glucose Study

Azra Ramezankhani  1 , Hadi Harati  1 , Mohammadreza Bozorgmanesh  1 , Maryam Tohidi  1 , Davood Khalili  1   2 , Fereidoun Azizi  1   3 , Farzad Hadaegh  1
Affiliations
Review

Diabetes Mellitus: Findings from 20 Years of the Tehran Lipid and Glucose Study

Azra Ramezankhani et al. Int J Endocrinol Metab. .

Abstract

Context: We summarized findings from Tehran lipid and glucose study (TLGS) about different aspects of type 2 diabetes (T2D) over the span of nearly 2 decades.

Evidence acquisition: A review was undertaken to retrieve papers related to all aspects of T2D from the earliest date available up to January 30, 2018.

Results: An annual crude incidence rate of 10 per 1000 person-years of follow-up was found for T2D in adult participants. Overall incidence rate of pre-diabetes/T2D was 36.3 per 1000 person-years or about 1% each year among youth. Diabetes was associated with increased risk of CVD [hazard ratio (HR): 1.86, 95% confidence interval (95% CI): 1.57 - 2.27] and mortality [HR: 2.56; 95% CI: 2.08 - 3.16] in the total population. Compared with non-diabetic men and women, their diabetic counterparts survived 1.4 and 0.7 years shorter, respectively, during 15 years of follow-up. Wrist circumference, hyperinsulinaemia, 25-hydroxy vitamin D and increase in alanin aminotranferase provided incremental prognostic information beyond the traditional risk factors for incident T2D in adults. Using decision tree algorithms, a number of high risk groups were found for incident T2D. A probability of 84% was found for incidence of T2D among a group of men with fasting plasma glucose (FPG) > 5.3 mmol/L and waist to height ratio (WHtR) > 0.56, and women with FPG > 5.2 mmol/L and WHtR > 0.56.

Conclusions: Original TLGS studies have contributed greatly to clarify important evidence regarding the epidemiology and risk factors for T2D among Iranian population.

Keywords: Cardiovascular Disease; Diabetes; Tehran Lipid and Glucose Study.

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