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. 2018 Dec 10;62(3):329-333.
doi: 10.2478/jvetres-2018-0034. eCollection 2018 Sep.

Simvastatin-induced Changes in the Leukocytic System of Porcine Bone Marrow

Anna Snarska  1 , Dominika Wysocka  1 , Liliana Rytel  1 , Sławomir Gonkowski  2 , Hanna Pawelec  1 , Przemysław Sobiech  1
Affiliations

Simvastatin-induced Changes in the Leukocytic System of Porcine Bone Marrow

Anna Snarska et al. J Vet Res. .

Abstract

Introduction: Simvastatin is a substance which is commonly used as a medicine to reduce cholesterol level. Unfortunately, it shows numerous side effects. Simvastatin affects various internal organs, and among other detriments to health may cause persistent muscle weakness, osteolytic processes, headaches, and rashes. Until now knowledge of the influence of simvastatin on bone marrow cells has been rather scant and fragmentary.

Material and methods: During this experiment the numbers of all types of cells in the leukocytic system of porcine bone marrow were evaluated after 28 and 56 days of oral administration of simvastatin at a dose of 40 mg/day/animal.

Results: Simvastatin caused an increase in the number of all types of cells in the leukocytic system, and the most visible fluctuations concerned promyelocytes.

Conclusion: Observations obtained during the present study indicated that the results of the action of simvastatin on porcine bone marrow differ from those observed in other mammal species, including human. This may be due to various metabolic pathways within the bone marrow in the particular species, but the exact mechanisms of these actions are unknown at the present time.

Keywords: bone marrow; leukocytic system; pig; statins.

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Conflict of interest statement

Conflict of Interests Statement: The authors declare that there is no conflict of interests regarding the publication of this article.

Figures

Fig. 1
Fig. 1
Myeloid cells in bone marrow smears A – prolymphocyte, B – eosinophilic myelocyte, C – lymphocytes, D – metamyelocyte, E – promyelocyte and lymphocyte, F – lymphoblast, eosinophilic myelocyte, G – neutrophilic granulocytes and monocyte, H – lymphocytes and prolymphocytes
Fig. 2
Fig. 2
Mevalonate pathway and the place of action of statins
See this image and copyright information in PMC

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