Effects of the antiprotease Trasylol on peripheral blood leucocytes
- PMID: 305854
- DOI: 10.1007/BF01935971
Effects of the antiprotease Trasylol on peripheral blood leucocytes
Abstract
Binding of the antiprotease Trasylol to human peripheral blood lymphocytes and polymorphonuclear leucocytes (PMNs) was demonstrated at the ultrastructural level using an indirect immunoperoxidase technique. This also revealed endocytosis of membrane bound Trasylol by PMNs. Trasylol inhibited PHA- and ConA-induced lymphocyte stimulation, and was cytotoxic to unstimulated cells.
Similar articles
-
Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.Br J Cancer. 1978 Jul;38(1):106-13. doi: 10.1038/bjc.1978.169. Br J Cancer. 1978. PMID: 308375 Free PMC article.
-
The polyvalent protease inhibitor, trasylol, inhibits DNA synthesis of mouse lymphocytes by an indirect mechanism.Cell Immunol. 1977 Dec;34(2):395-405. doi: 10.1016/0008-8749(77)90261-1. Cell Immunol. 1977. PMID: 303943 No abstract available.
-
[Trasylol effects. 3. Trasylol effect on the degranulation of circulating blood platelets and mobilization of neutrophilic granulocytes during experimental peritonitis].Blut. 1973 Mar;26(3):188-92. doi: 10.1007/BF01632362. Blut. 1973. PMID: 4540325 German. No abstract available.
-
Stimulation of lymphocytes of patients administered with a trypsin inhibitor, Trasylol (basic pancreatic trypsin inhibitor pharmaceutical), in vitro with BPTI and other several stimulants.Jpn J Exp Med. 1975 Dec;45(6):541-9. Jpn J Exp Med. 1975. PMID: 1085380
-
The serine antiprotease aprotinin (Trasylol): a novel approach to reducing postoperative bleeding.Blood Coagul Fibrinolysis. 1990 Mar-Apr;1(1):55-69. Blood Coagul Fibrinolysis. 1990. PMID: 1715200 Review.
Cited by
-
TEEM-test studies on effect of aprotinin on in vitro response of cancer patients' lymphocytes to PPD.Br J Cancer. 1978 Nov;38(5):636-8. doi: 10.1038/bjc.1978.262. Br J Cancer. 1978. PMID: 310312 Free PMC article. No abstract available.
-
On the biological role of a proteolytic-enzyme inhibitor from the ectoparasitic tick Boophilus microplus.Biochem J. 1980 Aug 1;189(2):295-303. doi: 10.1042/bj1890295. Biochem J. 1980. PMID: 7458913 Free PMC article.
-
Inhibition of neutrophil-mediated cytotoxicity by alpha 2 macroglobulin.Experientia. 1980 May 15;36(5):603-5. doi: 10.1007/BF01965827. Experientia. 1980. PMID: 6155288
-
Lymphocyte stimulation in vitro by proteinases and its augmentation with a proteinase binding factor from human skin.Arch Dermatol Res. 1978 Nov 10;263(2):223-6. doi: 10.1007/BF00446444. Arch Dermatol Res. 1978. PMID: 736607 No abstract available.
-
Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.Br J Cancer. 1978 Jul;38(1):106-13. doi: 10.1038/bjc.1978.169. Br J Cancer. 1978. PMID: 308375 Free PMC article.