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. 2018 Dec 27;18(1):700.
doi: 10.1186/s12879-018-3551-5.

Changing epidemiological patterns of HIV and AIDS in China in the post-SARS era identified by the nationwide surveillance system

Zhenqiu Liu  1   2   3   4 , Oumin Shi  5 , Qiong Yan  6 , Qiwen Fang  2   3 , Jialu Zuo  2   3 , Yue Chen  7 , Xingdong Chen  8   9   10 , Tiejun Zhang  11   12
Affiliations

Changing epidemiological patterns of HIV and AIDS in China in the post-SARS era identified by the nationwide surveillance system

Zhenqiu Liu et al. BMC Infect Dis. .

Abstract

Background: China has made substantial progress in tackling its HIV and AIDS epidemic. But the changing patterns of HIV and AIDS incidence based on the longitudinal observation data were rarely studied.

Methods: The reporting incidence (RI) and mortality data on HIV and AIDS in China covering 31 provinces from 2004 to 2014 were collected from the Chinese Public Health Science Data Center. To decompose the time-series data, Empirical Mode Decomposition (EMD) was applied to properly describe the trends of HIV and AIDS incidence. A mathematical model was used to estimate the relative change of incidence among provinces and age groups.

Results: A total of 483,010 newly HIV infections and 214,205 AIDS cases were reported between 2004 and 2014 nationwide. HIV infection increased from 13,258 in 2004 (RI 1.02 per 100,000 person years) to 74,048 in 2014 (RI 5.46 per 100,000). The number of AIDS cases increased from 3054 in 2004 (RI 0.23 per 100,000) to 45,145 in 2014 (RI 3.33 per 100,000). The overall relative changes for HIV infection and AIDS incidence were 1.11 (95% confidence interval [CI] 1.10-1.13) and 1.28 (95% CI 1.23-1.33), respectively. The relative increase for HIV and AIDS RI was higher in northwest provinces while lower in Henan, Xinjiang, Guangxi and Yunnan. The overall relative changes for HIV infection were 1.12 (95% CI 1.11-1.14) in males and 1.10 (95% CI 1.06-1.13) in females. For AIDS RI, the relative increases were 1.31 (95% CI 1.26-1.36) in males and 1.22 (95% CI 1.17-1.28) in females. The lowest relative increase was detected among young adults, while the largest relative increase (odds ratio [OR] > 1.30) was detected in people aged 55 years or above.

Conclusions: HIV and AIDS showed an increasing trend in China from 2004 to 2014, respectively, but the epidemic tended to be under control among provinces and young people that used to have a high HIV and AIDS incidence. Northwest China and older people could be new "hop-spots" for HIV and AIDS risk.

Keywords: China; Epidemiology; HIV and AIDS; Incidence; Surveillance.

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Conflict of interest statement

Ethics approval and consent to participate

This study was undertaken with the retrospective analysis of data collected from the Chinese Public Health Science Data Center, and the data used in the analysis were anonymized and no additional contact was made with patients to obtain further information as a part of this study, therefore, no ethical approval was required.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Monthly incidence of HIV and AIDS in China from 2004 to 2014. The gray smooth lines plotted in Fig. 1 were obtained from residues of EMD. (a: HIV monthly incidence from Jan, 2004 to Dec, 2014; b: AIDS monthly incidence from Jan, 2004 to Dec, 2014)
Fig. 2
Fig. 2
The distribution of HIV and AIDS cases by province in 2004 and 2014
Fig. 3
Fig. 3
The relative change (odds ratio) of HIV and AIDS incidences in China from 2004 to 2014. (The maps were derived from ggmap package in R program. BJ: Beijing, TJ: Tianjin, HB: Hebei, NMG: Inner Mongolia, SX: Shanxi, HLJ: Heilongjiang, JL: Jilin, LN: Liaoning, SD: Shandong, JS: Jiangsu, SH: Shanghai, ZJ: Zhejiang, AH: Anhui, FJ: Fujian, JX: Jiangxi, GD: Guangdong, GX: Guangxi, HN: Hainan, YN: Yunnan, GZ: Guizhou, XZ: Tibet, SC: Sichuan, CQ: Chongqing, HU: Hunan, HE: Hubei, HA: Henan, SA: Shaanxi, GS: Gansu, NX: Ningxia, QH: Qinghai, XJ: Xinjiang)
Fig. 4
Fig. 4
The distribution of HIV and AIDS cases by age in 2004 and 2014
Fig. 5
Fig. 5
The relative change (odds ratio) of HIV and AIDS incidence in each age group stratified by gender from 2004 to 2014. (※: p < 0.05)
Fig. 6
Fig. 6
The HIV and AIDS incidence in China in 2004 and 2014
Fig. 7
Fig. 7
The incidence of HIV and AIDS in each province stratified by regions in China from 2004 to 2014. (a: HIV incidence in China at province level; b: AIDS incidence in China at province level)
Fig. 8
Fig. 8
The HIV and AIDS mortality in China in 2004 and 2014
Fig. 9
Fig. 9
The relative change of mortality rate of HIV and AIDS in China at provincial level from 2004 to 2014
See this image and copyright information in PMC

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