Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 May;226(1):e13246.
doi: 10.1111/apha.13246. Epub 2019 Jan 16.

New evidence for fat as a primary taste quality

Dany Gaillard  1 , Sue C Kinnamon  2
Affiliations
Editorial

New evidence for fat as a primary taste quality

Dany Gaillard et al. Acta Physiol (Oxf). 2019 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: none

Figures

Figure 1.
Figure 1.. Putative function of GPR120 in taste receptor cells
The detection of fatty acids by CD36 triggers an IP3-dependent mobilization of endoplasmic reticulum calcium (Ca2+), which in turn mediates the depolarization of the cell and the release of neurotransmitters (NT) onto fat-best (F), dual fat/umami-best (F/M) and dual fat/sweet-best (F/S) gustatory nerve fibers. Binding of fatty acids to GPR120 augments intracellular Ca2+ resulting in the secretion of GLP1 onto F-, F/M- and F/S-best nerve fibers to modulate the coding of fat, umami and sweet perception, respectively. Altogether, fat taste regulates taste perception and eating behavior, as well as the cephalic phase of digestion to prepare the gastrointestinal system to digest the incoming food. For clarity purpose, and because both proteins are coexpressed in taste receptor cells, CD36 and GPR120 are represented in the same cell; however, this model may include expression of CD36 and GPR120 in distinct cells. Illustrations modified from Servier Medical Art licensed under a Creative Commons Attribution 3.0 Unported License (https://smart.servier.com/).
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Yasumatsu K, Iwata S, Inoue M, Ninomiya Y. Fatty acid taste quality information via GPR120 in the anterior tongue of mice. Acta Physiol (Oxf). 2018;0(ja):e13215 Epub 2018/10/31. doi: 10.1111/apha.13215. - DOI - PubMed
    1. Breslin PA. An evolutionary perspective on food and human taste. Curr Biol. 2013;23(9):R409–18. Epub 2013/05/11. doi: 10.1016/j.cub.2013.04.010. - DOI - PMC - PubMed
    1. Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature reviews. 2017;18(8):485–97. Epub 2017/06/29. doi: 10.1038/nrn.2017.68. - DOI - PMC - PubMed
    1. Besnard P, Passilly-Degrace P, Khan NA. Taste of Fat: A Sixth Taste Modality? Physiol Rev. 2016;96(1):151–76. Epub 2015/12/04. doi: 10.1152/physrev.00002.2015. - DOI - PubMed
    1. Cartoni C, Yasumatsu K, Ohkuri T, Shigemura N, Yoshida R, Godinot N, et al. Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci. 2010;30(25):8376–82. doi: 10.1523/JNEUROSCI.0496-10.2010. - DOI - PMC - PubMed