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Review
. 2018 Dec 27;14(12):e1007411.
doi: 10.1371/journal.ppat.1007411. eCollection 2018 Dec.

Deacetylated microbial biofilm exopolysaccharides: It pays to be positive

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Review

Deacetylated microbial biofilm exopolysaccharides: It pays to be positive

Hanna Ostapska et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Cationic exopolysaccharides play a role in microbial pathogenesis.
Deacetylated cationic exopolysaccharides mediate biofilm formation and adhere to microbial surfaces to protect microorganisms from host defenses and antimicrobials as detailed in the text. AMP, antimicrobial peptide; CW, cell wall; IM, inner membrane; M, membrane; NET, neutrophil extracellular trap; OM, outer membrane; PAMP, pathogen-associated molecular pattern; PG, peptidoglycan; PRR, pattern recognition receptor.

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References

    1. Vuong C, Kocianova S, Voyich JM, Yao Y, Fischer ER, DeLeo FR, et al. A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence. J Biol Chem 2004. December 24;279(52):54881–54886. 10.1074/jbc.M411374200 - DOI - PubMed
    1. Little DJ, Milek S, Bamford NC, Ganguly T, DiFrancesco BR, Nitz M, et al. The protein BpsB is a poly-beta-1,6-N-acetyl-D-glucosamine deacetylase required for biofilm formation in Bordetella bronchiseptica. J Biol Chem 2015. September 11;290(37):22827–22840. 10.1074/jbc.M115.672469 - DOI - PMC - PubMed
    1. Subashchandrabose S, Smith SN, Spurbeck RR, Kole MM, Mobley HL. Genome-wide detection of fitness genes in uropathogenic Escherichia coli during systemic infection. PLoS Pathog 2013;9(12):e1003788 10.1371/journal.ppat.1003788 - DOI - PMC - PubMed
    1. Bobrov AG, Kirillina O, Forman S, Mack D, Perry RD. Insights into Yersinia pestis biofilm development: topology and co-interaction of Hms inner membrane proteins involved in exopolysaccharide production. Environ Microbiol 2008. June;10(6):1419–1432. 10.1111/j.1462-2920.2007.01554.x - DOI - PubMed
    1. Jennings LK, Storek KM, Ledvina HE, Coulon C, Marmont LS, Sadovskaya I, et al. Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix. Proc Natl Acad Sci U S A 2015. September 8;112(36):11353–11358. 10.1073/pnas.1503058112 - DOI - PMC - PubMed

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