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. 2019 Jul 18;69(3):534-537.
doi: 10.1093/cid/ciy1112.

A Cluster of Cefepime-induced Neutropenia During Outpatient Parenteral Antimicrobial Therapy

Kap Sum Foong  1 , Kevin Hsueh  1 , Thomas C Bailey  1 , Lan Luong  2 , Ayesha Iqbal  2 , Christine Hoehner  2 , Lee Connor  1 , Ed Casabar  3 , Michael Lane  1 , Yvonne Burnett  1   4 , David Ritchie  3   4 , Tamara Krekel  3 , Helen Newland  3 , Lori Weilmuenster  5 , Brett Heuring  5 , Michael J Durkin  1 , Yasir Hamad  1
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A Cluster of Cefepime-induced Neutropenia During Outpatient Parenteral Antimicrobial Therapy

Kap Sum Foong et al. Clin Infect Dis. .

Abstract

A cluster of cefepime-induced neutropenia (CIN) was identified from June 2017 to May 2018 in a regional outpatient parenteral antimicrobial therapy population. Our data suggest prolonged courses of cefepime (≥2 weeks), administered by rapid intravenous push, were associated with a higher risk of CIN.

Keywords: OPAT; adverse drug event; cefepime; cefepime-induced neutropenia; drug-induced neutropenia.

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Figures

Figure 1.
Figure 1.
Epidemic curve of cefepime-induced neutropenia from January 2016 to May 2018.
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