Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

doi:10.1016/j.clinthera.2018.11.007

Comparative Study

. 2019 Jan;41(1):130-136.

doi: 10.1016/j.clinthera.2018.11.007. Epub 2018 Dec 24.

Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

Remon Helmy¹, Samira Scalso de Almeida², Kris Denhaerynck¹, Lut Berben³, Fabienne Dobbels⁴, Cynthia L Russell⁵, Bartira de Aguiar Roza⁶, Sabina De Geest⁷; BRIGHT study team

Collaborators, Affiliations

Collaborators

BRIGHT study team:
Marisa G Crespo-Leiro⁸, Sandra Cupples⁹, Paolo De Simone¹⁰, Albert Groenewoud¹¹, Christiane Kugler¹², Linda Ohler¹³, Johan Van Cleemput¹⁴, Alain Jean Poncelet¹⁵, Laurent Sebbag¹⁶, Magali Michel¹⁷, Andrée Bernard¹⁸, Andreas Doesch¹⁹, Ugolino Livi²⁰, Luciano Potena²¹, Vicens Brossa-Loidi²², Javier Segovia-Cubero²³, Luis Almenar-Bonet²⁴, Carmen Segura Saint-Gerons²⁵, Paul Mohacsi²⁶, Eva Horvath²⁷, Cheryl Riotto²⁸, Gareth Parry²⁹, Ashi Firouzi³⁰, Stella Kozuszko³¹, Haissam Haddad³², Annemarie Kaan³³, Grant Fisher³⁴, Tara Miller³⁵, Maureen Flattery³⁶, Kristin Ludrosky³⁷, Nancy Albert³⁷, Bernice Coleman³⁸, Jacqueline Trammell³⁹, Flavio Epstein³⁹, Katherine St Clair⁴⁰, Andrew Kao⁴⁰, Maria Molina⁴¹, Karyn Ryan Canales⁴², Samira Scalso de Almeida⁴³, Andrea Cotait Ayoub⁴⁴, Fernanda Barone⁴⁵, Michelle Harkess⁴⁶, Joanne Maddicks-Law⁴⁷

Affiliations

¹ Institute of Nursing Science, Department Public Health, Faculty of Medicine, University of Basel, Basel, Switzerland.
² Hospital Municipal Vila Santa Catarina - Ministério da Saúde PROADI-SUS, São Paulo, Brazil; School of Nursing, Federal University of São Paulo, São Paolo, Brazil.
³ Institute of Nursing Science, Department Public Health, Faculty of Medicine, University of Basel, Basel, Switzerland; University Hospital Basel, Basel, Switzerland.
⁴ Academic Centre for Nursing and Midwifery, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
⁵ School of Nursing and Health Studies, University of Missouri, Kansas City, MO, USA.
⁶ School of Nursing, Federal University of São Paulo, São Paolo, Brazil.
⁷ Institute of Nursing Science, Department Public Health, Faculty of Medicine, University of Basel, Basel, Switzerland; Academic Centre for Nursing and Midwifery, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium. Electronic address: sabina.degeest@unibas.ch.
⁸ Complexo Hospitalario Universitario A Coruña, CIBERCV, INIBIC, Universidade da Coruña, La Coruña, Spain.
⁹ US Department of Veterans Affairs, Veterans Health Administration, Washington, DC, USA.
¹⁰ Azienda Ospedaliero-Universitaria Pisana, Ospedale Cisanello, Pisa, Italy.
¹¹ Astellas Pharma Europe Ltd, UK.
¹² Hannover Medical School, Hannover, Germany.
¹³ George Washington University, Washington, DC, USA.
¹⁴ University Hospitals Leuven, Leuven, Belgium.
¹⁵ Cliniques Universitaires Saint-Luc, Brussels, Belgium.
¹⁶ Hôpital Louis Pradel, Lyon, France.
¹⁷ Hôpital Nord Laennec, Nantes, France.
¹⁸ Hôpital Universitaire Pitié-Salpêtrière, Paris, France.
¹⁹ University Hospital Heidelberg, Heidelberg, Germany.
²⁰ University Hospital Udine, Udine, Italy.
²¹ University of Bologna, Bologna, Italy.
²² Hospital de Sant Pau, Barcelona, Spain.
²³ Hospital Puerta de Hierro, Madrid, Spain.
²⁴ Hospital Universitari i Politècnic La Fe de Valencia, Valencia, Spain.
²⁵ Hospital Univeritario Reina Sofia, Córdoba, Spain.
²⁶ University Hospital of Bern, Bern, Switzerland.
²⁷ University Hospital Zurich, Zurich, Switzerland.
²⁸ Papworth Hospital, Cambridge, UK.
²⁹ Freeman Hospital, Newcastle, UK.
³⁰ Royal Brompton & Harefield NHS Foundation Trust, London, UK.
³¹ Toronto General Hospital, Toronto, Ontario, Canada.
³² University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
³³ St Paul's Hospital, Vancouver, British Columbia, Canada.
³⁴ London Health Sciences Centre, London, Ontario, Canada.
³⁵ Duke University Hospital, Durham, NC, USA.
³⁶ Virginia Commonwealth University Health System, Richmond, VA, USA.
³⁷ Cleveland Clinic, Cleveland, OH, USA.
³⁸ Cedars-Sinai Medical Center, Los Angeles, Calfornia, USA.
³⁹ Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA, USA.
⁴⁰ St. Luke's Hospital, Kansas City, MO, USA.
⁴¹ Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
⁴² Ochsner Medical Center, New Orleans, LA, USA.
⁴³ Hospital Israelita Albert Einstein, São Paulo & Paulista Nursing School, Universidade Federal de São Paulo, Brazil.
⁴⁴ Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil.
⁴⁵ Instituto do Coração da Universidade de São Paulo, São Paulo Brazil.
⁴⁶ St. Vincent's Hospital, Sydney, Australia.
⁴⁷ The Prince Charles Hospital, Brisbane, Australia.

PMID: 30591285
DOI: 10.1016/j.clinthera.2018.11.007

Free article

Comparative Study

Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

Remon Helmy et al. Clin Ther. 2019 Jan.

Free article

. 2019 Jan;41(1):130-136.

doi: 10.1016/j.clinthera.2018.11.007. Epub 2018 Dec 24.

Authors

Remon Helmy¹, Samira Scalso de Almeida², Kris Denhaerynck¹, Lut Berben³, Fabienne Dobbels⁴, Cynthia L Russell⁵, Bartira de Aguiar Roza⁶, Sabina De Geest⁷; BRIGHT study team

Collaborators

BRIGHT study team:
Marisa G Crespo-Leiro⁸, Sandra Cupples⁹, Paolo De Simone¹⁰, Albert Groenewoud¹¹, Christiane Kugler¹², Linda Ohler¹³, Johan Van Cleemput¹⁴, Alain Jean Poncelet¹⁵, Laurent Sebbag¹⁶, Magali Michel¹⁷, Andrée Bernard¹⁸, Andreas Doesch¹⁹, Ugolino Livi²⁰, Luciano Potena²¹, Vicens Brossa-Loidi²², Javier Segovia-Cubero²³, Luis Almenar-Bonet²⁴, Carmen Segura Saint-Gerons²⁵, Paul Mohacsi²⁶, Eva Horvath²⁷, Cheryl Riotto²⁸, Gareth Parry²⁹, Ashi Firouzi³⁰, Stella Kozuszko³¹, Haissam Haddad³², Annemarie Kaan³³, Grant Fisher³⁴, Tara Miller³⁵, Maureen Flattery³⁶, Kristin Ludrosky³⁷, Nancy Albert³⁷, Bernice Coleman³⁸, Jacqueline Trammell³⁹, Flavio Epstein³⁹, Katherine St Clair⁴⁰, Andrew Kao⁴⁰, Maria Molina⁴¹, Karyn Ryan Canales⁴², Samira Scalso de Almeida⁴³, Andrea Cotait Ayoub⁴⁴, Fernanda Barone⁴⁵, Michelle Harkess⁴⁶, Joanne Maddicks-Law⁴⁷

Affiliations

¹ Institute of Nursing Science, Department Public Health, Faculty of Medicine, University of Basel, Basel, Switzerland.
² Hospital Municipal Vila Santa Catarina - Ministério da Saúde PROADI-SUS, São Paulo, Brazil; School of Nursing, Federal University of São Paulo, São Paolo, Brazil.
³ Institute of Nursing Science, Department Public Health, Faculty of Medicine, University of Basel, Basel, Switzerland; University Hospital Basel, Basel, Switzerland.
⁴ Academic Centre for Nursing and Midwifery, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
⁵ School of Nursing and Health Studies, University of Missouri, Kansas City, MO, USA.
⁶ School of Nursing, Federal University of São Paulo, São Paolo, Brazil.
⁷ Institute of Nursing Science, Department Public Health, Faculty of Medicine, University of Basel, Basel, Switzerland; Academic Centre for Nursing and Midwifery, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium. Electronic address: sabina.degeest@unibas.ch.
⁸ Complexo Hospitalario Universitario A Coruña, CIBERCV, INIBIC, Universidade da Coruña, La Coruña, Spain.
⁹ US Department of Veterans Affairs, Veterans Health Administration, Washington, DC, USA.
¹⁰ Azienda Ospedaliero-Universitaria Pisana, Ospedale Cisanello, Pisa, Italy.
¹¹ Astellas Pharma Europe Ltd, UK.
¹² Hannover Medical School, Hannover, Germany.
¹³ George Washington University, Washington, DC, USA.
¹⁴ University Hospitals Leuven, Leuven, Belgium.
¹⁵ Cliniques Universitaires Saint-Luc, Brussels, Belgium.
¹⁶ Hôpital Louis Pradel, Lyon, France.
¹⁷ Hôpital Nord Laennec, Nantes, France.
¹⁸ Hôpital Universitaire Pitié-Salpêtrière, Paris, France.
¹⁹ University Hospital Heidelberg, Heidelberg, Germany.
²⁰ University Hospital Udine, Udine, Italy.
²¹ University of Bologna, Bologna, Italy.
²² Hospital de Sant Pau, Barcelona, Spain.
²³ Hospital Puerta de Hierro, Madrid, Spain.
²⁴ Hospital Universitari i Politècnic La Fe de Valencia, Valencia, Spain.
²⁵ Hospital Univeritario Reina Sofia, Córdoba, Spain.
²⁶ University Hospital of Bern, Bern, Switzerland.
²⁷ University Hospital Zurich, Zurich, Switzerland.
²⁸ Papworth Hospital, Cambridge, UK.
²⁹ Freeman Hospital, Newcastle, UK.
³⁰ Royal Brompton & Harefield NHS Foundation Trust, London, UK.
³¹ Toronto General Hospital, Toronto, Ontario, Canada.
³² University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
³³ St Paul's Hospital, Vancouver, British Columbia, Canada.
³⁴ London Health Sciences Centre, London, Ontario, Canada.
³⁵ Duke University Hospital, Durham, NC, USA.
³⁶ Virginia Commonwealth University Health System, Richmond, VA, USA.
³⁷ Cleveland Clinic, Cleveland, OH, USA.
³⁸ Cedars-Sinai Medical Center, Los Angeles, Calfornia, USA.
³⁹ Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA, USA.
⁴⁰ St. Luke's Hospital, Kansas City, MO, USA.
⁴¹ Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
⁴² Ochsner Medical Center, New Orleans, LA, USA.
⁴³ Hospital Israelita Albert Einstein, São Paulo & Paulista Nursing School, Universidade Federal de São Paulo, Brazil.
⁴⁴ Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil.
⁴⁵ Instituto do Coração da Universidade de São Paulo, São Paulo Brazil.
⁴⁶ St. Vincent's Hospital, Sydney, Australia.
⁴⁷ The Prince Charles Hospital, Brisbane, Australia.

PMID: 30591285
DOI: 10.1016/j.clinthera.2018.11.007

Abstract

Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients.

Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries.

Findings: MNA was significantly (α = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20).

Implications: The observed MNA necessitates adherence-enhancing interventions encompassing the entire post-heart transplant medication regimen. ClinicalTrials.gov identifier: NCT01608477.

Keywords: co-medications; cross-sectional; heart transplantation; immunosuppressants; international; medication adherence.

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Nonadherence to Immunosuppressants Among Transplant Recipients: Emotional Intelligence as a Predictive Factor During COVID-19 Pandemic.
De Pasquale C, Barbagallo N, Veroux M, Pistorio ML, Zerbo D, Giaquinta A, Ekser B, Veroux P. De Pasquale C, et al. Patient Prefer Adherence. 2023 Nov 27;17:3083-3092. doi: 10.2147/PPA.S426358. eCollection 2023. Patient Prefer Adherence. 2023. PMID: 38045111 Free PMC article.

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Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

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Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

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