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Review
. 2019 Jan;39(1):1-16.
doi: 10.21873/anticanres.13074.

Evolution of Cancer Progression in the Context of Darwinism

Lukáš Lacina  1   2   3 , Matúš Čoma  4   5 , Barbora Dvořánková  1   2 , Ondřej Kodet  1   2   3 , Nikola Melegová  4 , Peter Gál  6   5   7 , Karel Smetana Jr  8   2
Affiliations
Review

Evolution of Cancer Progression in the Context of Darwinism

Lukáš Lacina et al. Anticancer Res. 2019 Jan.

Abstract

Our review compares evolution of cancer in the human body to the origin of new species from a common ancestor organism with respect to the theory of Charles Darwin. Moreover, the functional role of the tumor microenvironment as a selective pressure actively participating in cancer progression is also demonstrated. Evolutionary aspects of tumor growth and invasion from the point of view of modern therapeutic challenges and opportunities in precision personalized medicine are also discussed.

Keywords: Tumor microenvironment; cancer ecology; prognosis; regeneration; review; species development; stem cells; wound healing.

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