Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Jan 2;139(1):64-66.
doi: 10.1161/CIRCULATIONAHA.118.037171.

Tale of 2 Endothelin Receptor Antagonists in Eisenmenger Syndrome

Affiliations
Editorial

Tale of 2 Endothelin Receptor Antagonists in Eisenmenger Syndrome

Dunbar Ivy et al. Circulation. .

Erratum in

No abstract available

Keywords: Editorials; Eisenmenger syndrome; congenital heart disease; endothelin receptor antagonist; pulmonary hypertension.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosure: The University of Colorado contracts with Actelion, Bayer, Lilly and United Therapeutics for Dr Ivy to be a consultant and perform clinical trials.

Comment on

  • Evaluation of Macitentan in Patients With Eisenmenger Syndrome.
    Gatzoulis MA, Landzberg M, Beghetti M, Berger RM, Efficace M, Gesang S, He J, Papadakis K, Pulido T, Galiè N; MAESTRO Study Investigators. Gatzoulis MA, et al. Circulation. 2019 Jan 2;139(1):51-63. doi: 10.1161/CIRCULATIONAHA.118.033575. Circulation. 2019. PMID: 30586694 Free PMC article. Clinical Trial.

References

    1. Wood P The Eisenmenger syndrome or pulmonary hypertension with reversed central shunt. Br Med J. 1958;2:755–62. - PMC - PubMed
    1. Hjortshoj CS, Jensen AS, Sorensen K, Nagy E, Johansson B, Kronvall T, Dellborg M, Estensen ME, Holmstrom H, Turanlahti M, Thilen U and Sondergaard L. Epidemiological changes in Eisenmenger syndrome in the Nordic region in 1977–2012. Heart. 2017;103:1353–1358. - PubMed
    1. Manes A, Palazzini M, Leci E, Bacchi Reggiani ML, Branzi A and Galie N. Current era survival of patients with pulmonary arterial hypertension associated with congenital heart disease: a comparison between clinical subgroups. Eur Heart J. 2014;35:716–724. - PubMed
    1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K and Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411–415. - PubMed
    1. Galie N, Beghetti M, Gatzoulis MA, Granton J, Berger RM, Lauer A, Chiossi E, Landzberg M and Bosentan Randomized Trial of Endothelin Antagonist Therapy I. Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study. Circulation. 2006;114:48–54. - PubMed