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Review
. 2018 Dec 1;36(6):686-690.
doi: 10.7518/hxkq.2018.06.020.

[Relationship between thrombospondin-1 and the occurrence and development of oral and maxillofacial malignancy]

[Article in Chinese]
Xue-Qin Zhou  1 , Jun Ren  1 , Sen Yang  1
Affiliations
Review

[Relationship between thrombospondin-1 and the occurrence and development of oral and maxillofacial malignancy]

[Article in Chinese]
Xue-Qin Zhou et al. Hua Xi Kou Qiang Yi Xue Za Zhi. .

Abstract
in English, Chinese

Thrombospondin-1 (TSP-1) is widely distributed in human tissues and is important in inhibiting angiogenesis.It also occupies an indispensable position in the formation, growth, differentiation, and metastasis of tumors in different tissues.TSP-1 plays an important role in the occurrence and development of various types of tumors. The inhibitory effect of TSP-1 on the angiogenesis and tumor development of oral and maxillofacial malignant tumors has been demonstrated in recent years. This paper reviews the findings and progress of TSP-1 research involving all kinds of tumors as well as oral and maxillofacial malignancies.

凝血酶敏感蛋白- 1（TSP-1）作为一种重要的抑制血管生成物质，在人体组织中广泛分布，并且在不同组织部位肿瘤的形成、生长、分化、转移中占据不可代替的地位。TSP-1在各类肿瘤（如膀胱癌、乳腺癌、前列腺癌、非小细胞肺癌、胰腺癌等）的发生、发展中起着重要的作用，近年研究证实凝血酶敏感蛋白-1对口腔颌面部恶性肿瘤血管生成及肿瘤发生、发展的抑制作用也尤为明显。本文对TSP-1在全身肿瘤及口腔颌面部恶性肿瘤中的研究进展进行综述。.

Keywords: oral and maxillofacial malignancy; solid tumor; thrombospondin-1; vascular suppression.

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References

    1. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease[J] Nat Med. 1995;1(1):27–30. - PubMed
    1. Weng TY, Huang SS, Yen MC, et al. A novel cancer therapeutic using thrombospondin 1 in dendritic cells[J] Mol Ther. 2014;22(2):292–302. - PMC - PubMed
    1. 张 志愿, 俞 光岩. 口腔颌面外科学[M] 7版. Vol. 2012. 北京: 人民卫生出版社; p. 281.
    2. Zhang ZY, Yu GY. Oral and maxillofacial surgery[M] 7th ed. Vol. 2012. Beijing: People's Medical Publishing House; p. 281.
    1. Schadler KL, Crosby EJ, Zhou AY, et al. Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1[J] Cancer Res. 2014;74(8):2171–2181. - PMC - PubMed
    1. Amagasaki K, Sasaki A, Kato G, et al. Antisense-mediated reduction in thrombospondin-1 expression reduces cell motility in malignant gliomacells[J] Int J Cancer. 2001;94(4):508–512. - PubMed

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