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Review
. 2018 Dec 28;10(1):101.
doi: 10.1186/s13073-018-0612-8.

Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response

Paola Francica  1 , Sven Rottenberg  2   3
Affiliations
Review

Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response

Paola Francica et al. Genome Med. .

Abstract

Inhibitors of poly(ADP-ribose) polymerase (PARPi) have entered the clinic for the treatment of patients with cancers that lack homology-directed DNA repair, but drug resistance remains a clinical hurdle. Recent advances in the identification of PARPi resistance mechanisms have yielded a better understanding of DNA end protection and the relevance of endogenous poly(ADP-ribose) glycohydrolase, highlighting new vulnerabilities.

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Conflict of interest statement

Competing interests

The authors declare that they have no competing interests.

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References

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