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Clinical Trial
. 2019 Jun;16(6):846-852.
doi: 10.1016/j.hrthm.2018.12.024. Epub 2018 Dec 26.

Safety and outcomes of catheter ablation for atrial fibrillation in adults with congenital heart disease: A multicenter registry study

Jackson J Liang  1 , David S Frankel  1 , Valay Parikh  2 , Dhanujaya Lakkireddy  2 , Sanghamitra Mohanty  3 , J David Burkhardt  3 , Andrea Natale  3 , Judit Szilagyi  4 , Edward P Gerstenfeld  4 , Jeremy P Moore  5 , Kathryn K Collins  6 , Joseph D Kay  7 , Pasquale Santangeli  1 , Francis E Marchlinski  1 , William H Sauer  7 , Duy T Nguyen  8
Affiliations
Clinical Trial

Safety and outcomes of catheter ablation for atrial fibrillation in adults with congenital heart disease: A multicenter registry study

Jackson J Liang et al. Heart Rhythm. 2019 Jun.

Abstract

Background: An increasing number of adults with congenital heart disease (CHD) are undergoing catheter ablation for atrial fibrillation (AF). Data on ablation strategy and outcomes in CHD are limited. Rhythm control is often believed to be of greater importance among patients with complex CHD.

Objective: The purpose of this study was to examine the safety and efficacy of AF ablation in adult patients with CHD.

Methods: A multicenter retrospective analysis was performed of CHD patients undergoing AF ablation. Clinical data were collected, including AF and CHD type, procedural data, and outcomes. Patients were divided into 3 groups (simple, moderate, and severe) based on CHD complexity, as defined by the 2014 PACES/HRS (Pediatric and Congenital Electrophysiology Society/Heart Rhythm Society) consensus statement. One-year procedural success was defined as freedom from recurrent AF, off antiarrhythmic drugs (complete) or off/on previously failed antiarrhythmic drugs (partial).

Results: Overall, 84 CHD patients (mean age 51.5 ± 12.1 years; 65.5% male; 45.2% with paroxysmal AF) undergoing AF ablation (51 simple, 22 moderate, 11 severe complexity) were included. Pulmonary vein isolation was performed in 80 (95.2%), of whom 30 (35.7%) underwent pulmonary vein isolation alone. Overall, complete and complete/partial freedom was achieved at 1 year in 53.1% and 71.6%, respectively, with no significant differences between those with simple, moderate, or severe complexity. There were no major complications and 7 minor complications, and 2 patients died during follow-up.

Conclusion: There are dramatic differences in the degree of CHD complexity among patients referred for AF ablation. When performed at experienced centers, AF ablation is safe and effective even among patients with the most complex forms of CHD.

Keywords: Atrial fibrillation; Catheter ablation; Complexity; Congenital heart disease.

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