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Observational Study
. 2018 Dec;70 Suppl 3(Suppl 3):S280-S284.
doi: 10.1016/j.ihj.2018.05.014. Epub 2018 May 26.

Seven-year clinical outcomes in patients undergoing percutaneous coronary intervention with biodegradable polymer coated sirolimus-eluting stent: Results from a single-center real-world experience

Atul Abhyankar  1 , Upendra Kaul  2 , Santosh Kumar Sinha  3
Affiliations
Observational Study

Seven-year clinical outcomes in patients undergoing percutaneous coronary intervention with biodegradable polymer coated sirolimus-eluting stent: Results from a single-center real-world experience

Atul Abhyankar et al. Indian Heart J. 2018 Dec.

Abstract

Objective: The aim of the present study was to assess seven-year clinical outcomes of biodegradable polymer coated Supralimus sirolimus-eluting stent (S-SES) [Sahajanand Medical Technologies Pvt. Ltd., Surat, India] in real-world patients with coronary artery disease.

Methods: This observational, retrospective study was carried out in all 346 consecutive enrolled patients who underwent percutaneous coronary intervention (PCI) with the S-SES, between April 2008 and December 2009, at a single center. We analyzed major adverse cardiac events (MACE) [a composite of cardiac death, myocardial infarction (MI), target lesion revascularization (TLR) and target vessel revascularization (TVR)] as primary outcomes at seven-year follow-up.

Results: Out of 346 patients, seven-year follow-up was obtained in 327 (94.5%) patients and hence results were analyzed for 327 patients. At seven-year, MACE occurred in 41 (12.5%) patients, consisting of 23 (7.0%) cardiac deaths, 14 (4.3%) TLR, and 4 (1.2%) TVR. The incidence of late stent thrombosis was observed in 3 (0.9%) patients. At follow-up of seven-year, the cumulative event-free survival was found to be 84.7% by Kaplan-Meier method.

Conclusions: The present study demonstrated satisfactory and sustained seven-year clinical outcomes as evidenced by the low rates of MACE and ST for the biodegradable polymer coated S-SES.

Keywords: Biodegradable polymer; Coronary artery lesion; Percutaneous coronary intervention; Sirolimus-eluting stent.

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Fig. 1
Kaplan-Meier curve of cumulative event-free survival over seven-year.
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References

    1. Moses J.W., Leon M.B., Popma J.J. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med. 2003;349:1315–1323. - PubMed
    1. Babapulle M.N., Joseph L., Belisle P. A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stents. Lancet. 2004;364:583–591. - PubMed
    1. Chamie D., Abizaid A., Costa J.R., Jr. Serial angiographic and intravascular ultrasound evaluation to interrogate the presence of late catch-up phenomenon after Cypher(R) sirolimus-eluting stent implantation. Int J Cardiovasc Imaging. 2011;27:867–874. - PubMed
    1. Nebeker J.R., Virmani R., Bennett C.L. Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project. J Am Coll Cardiol. 2006;47:175–181. - PubMed
    1. Virmani R., Guagliumi G., Farb A. Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious. Circulation. 2004;109:701–705. - PubMed

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