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Review
. 2018 Jul 1;12(3):235-248.

Liquid Biopsy in Thyroid Cancer: New Insight

Fatemeh Khatami  1 , Seyed Mohammad Tavangar  1   2
Affiliations
Review

Liquid Biopsy in Thyroid Cancer: New Insight

Fatemeh Khatami et al. Int J Hematol Oncol Stem Cell Res. .

Abstract

Thyroid cancer, one of the most widespread malignancies of the endocrine-related system that over the past three decades, has a vivid increasing rate. The diagnosis and management of it is dependent on the tumor type and stage. Thyroid cancer is divided into four main types, including PTC (papillary thyroid carcinoma), FTC (follicular thyroid carcinoma), MTC (medullarly thyroid carcinoma), and ATC (anaplastic thyroid carcinoma). The development of the noninvasive diagnostic tool for plasma genotyping, also known as "liquid biopsy", brings a new insight for cancer diagnosis and prognosis. It is mainly containing circulating tumor DNA (ctDNA), circulating tumor cell (CTC), exosomes and extrachromosomal circular DNA (ecDNA). Liquid biopsy as a new plasma genotyping source brings a new prospective of tumor monitoring and therapy. It beneficially reduces the need of tissue biopsy and made early recognition of relapse as well. This article summarizes its components characteristics and their benefit in diagnosis and treatment of thyroid cancer.

Keywords: Biopsy; CTCs; Carcinoma; Endocrine system diseases; Thyroid cancer; cfDNA.

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Figures

Figure1
Figure1
Main components of liquid biopsy for genetic and epigenetic analysis of thyroid tumors.
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