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. 2017 Oct-Dec;43(4):325-329.
doi: 10.12865/CHSJ.43.04.06. Epub 2017 Dec 28.

P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma

Liliana Cercelaru  1 , A E Stepan  1 , C Mărgăritescu  1 , A Osman  2 , Ionelia-Carmen Popa  1 , Cristiana Eugenia Simionescu  1 , Otilia Mărgăritescu  3
Affiliations

P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma

Liliana Cercelaru et al. Curr Health Sci J. 2017 Oct-Dec.

Abstract

p53 is a marker described in the premalignant lesions with a high risk of malignant transformation for laryngeal cancer. It is a tumor suppressor gene that during the cancer gains also oncogenic activity. We aimed to study the p53 immunoexpression in 38 cases of laryngeal squamous cell carcinomas and the relation with the clinicopathological aspects. We obtained variable p53 expression regarding the differentiation degree and tumor stage. The higher p53 immunotaining values were observed in high grade and advanced stages lesions. P53 may be useful in identifying aggresive laryngeal squamous carcinomas, a useful aspect for better stratification of patients for therapy.

Keywords: laryngeal squamous cell carcinoma; p53.

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Figures

Figure 1
Figure 1
Well differentiated laryngeal squamous cell carcinoma, p53 immunostaining, x100
Figure 2
Figure 2
Moderate differentiated laryngeal squamous cell carcinoma, p53 immunostaining, x100
Figure 3
Figure 3
Poorly differentiated laryngeal squamous cell carcinoma, p53 immunostaining, x100
Figure 4
Figure 4
Cases distribution according to the scores of p53 and the differentiation degree
Figure 5
Figure 5
Cases distribution according to the scores of p53 and the pTNM stages
See this image and copyright information in PMC

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