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Meta-Analysis
. 2018 Nov 26:2018:5340894.
doi: 10.1155/2018/5340894. eCollection 2018.

Prognostic Value of Long Noncoding RNAs in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis

Weibiao Kang  1 , Qiang Zheng  1 , Jun Lei  2 , Changyu Chen  3 , Changjun Yu  1
Affiliations
Meta-Analysis

Prognostic Value of Long Noncoding RNAs in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis

Weibiao Kang et al. Dis Markers. .

Abstract

Gastrointestinal cancers (GICs) are a huge threat to human health, which mainly include esophageal, gastric, and colorectal cancers. The purpose of this study was to clarify the prognostic value of long noncoding RNAs (lncRNAs) in GICs. A total of 111 articles were included, and 13103 patients (3123 with esophageal cancer, 4972 with gastric cancer, and 5008 with colorectal cancer) were enrolled in this study. The pooled hazard ratio (HR) values and corresponding 95% confidence interval (95% CI) of overall survival (OS) related to different lncRNA expressions in esophageal, gastric, colorectal, and gastrointestinal cancer patients were 1.92 (1.70-2.16), 1.96 (1.77-2.16), 2.10 (1.87-2.36), and 2.00 (1.87-2.13), respectively. We have identified 74 lncRNAs which were associated closely with poor prognosis of GIC patients, including 58 significantly upregulated lncRNA expression and 16 significantly downregulated lncRNA expression. In addition, 47 of the included studies revealed relative mechanisms and 12 of them investigated the correlation between lncRNAs and microRNAs. Taken together, this meta-analysis supports that specific lncRNAs are significantly related to the prognosis of GIC patients and may serve as novel markers for predicting the prognosis of GIC patients. Furthermore, lncRNAs may have a promising contribution to lncRNA-based targeted therapy and clinical decision-making in the future.

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Figures

Figure 1
Figure 1
Study flow diagram.
Figure 2
Figure 2
Forest plot showing the pooled HR and corresponding 95% CI of OS related to the expression level of lncRNA UCA1 in gastrointestinal cancer patients. HR: hazard ratio; CI: confidence interval; OS: overall survival.
Figure 3
Figure 3
Forest plot showing the pooled HR (95% CI) of OS related to the expression level of different lncRNAs in gastrointestinal cancer patients. (1.1.1) Specific lncRNA expression in EC (esophageal cancer); (1.1.2) specific lncRNA expression in GC (gastric cancer); (1.1.3) specific lncRNA expression in CRC (colorectal cancer). HR: hazard ratio; CI: confidence interval; OS: overall survival.
Figure 4
Figure 4
Forest plot showing the pooled HR (95% CI) of DFS related to the expression level of different lncRNAs in GIC patients. HR: hazard ratio; CI: confidence interval; DFS: disease-free survival; GIC: gastrointestinal cancer.
Figure 5
Figure 5
Funnel plot of included studies: highly expressed lncRNA UCA1 related to overall survival in gastrointestinal cancer patients.
Figure 6
Figure 6
Funnel plot of included studies: aberrantly expressed lncRNAs related to overall survival in gastrointestinal cancer patients. EC: esophageal cancer; GC: gastric cancer; CRC: colorectal cancer.
Figure 7
Figure 7
Funnel plot of included studies: aberrantly expressed lncRNAs related to disease-free survival in gastrointestinal cancer patients.
See this image and copyright information in PMC

References

    1. Jemal A., Bray F., Center M. M., Ferlay J., Ward E., Forman D. Global Cancer statistics. CA: a Cancer Journal for Clinicians. 2011;61(2):69–90. doi: 10.3322/caac.20107. - DOI - PubMed
    1. Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2014 (ver. 4) Gastric Cancer. 2017;20(1):1–19. doi: 10.1007/s10120-016-0622-4. - DOI - PMC - PubMed
    1. Suzuki H., Gotoda T., Sasako M., Saito D. Detection of early gastric cancer: misunderstanding the role of mass screening. Gastric Cancer. 2006;9(4):315–319. doi: 10.1007/s10120-006-0399-y. - DOI - PubMed
    1. McFarland E. G., Levin B., Lieberman D. A., et al. Revised colorectal screening guidelines: joint effort of the American Cancer Society, U.S. Multisociety Task Force on Colorectal Cancer, and American College of Radiology. Radiology. 2008;248(3):717–720. doi: 10.1148/radiol.2483080842. - DOI - PubMed
    1. Zheng Q., Chen C., Guan H., Kang W., Yu C. Prognostic role of microRNAs in human gastrointestinal cancer: a systematic review and meta-analysis. Oncotarget. 2017;8(28):46611–46623. doi: 10.18632/oncotarget.16679. - DOI - PMC - PubMed

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