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Review
. 2018 Dec 20:22:37.
doi: 10.1186/s40824-018-0147-5. eCollection 2018.

Silicone breast implant modification review: overcoming capsular contracture

Byung Ho Shin  1 , Byung Hwi Kim  1 , Sujin Kim  2 , Kangwon Lee  2   3 , Young Bin Choy  1   4   5 , Chan Yeong Heo  4   6   7
Affiliations
Review

Silicone breast implant modification review: overcoming capsular contracture

Byung Ho Shin et al. Biomater Res. .

Abstract

Background: Silicone implants are biomaterials that are frequently used in the medical industry due to their physiological inertness and low toxicity. However, capsular contracture remains a concern in long-term transplantation. To date, several studies have been conducted to overcome this problem. This review summarizes and explores these trends.

Main body: First, we examined the overall foreign body response from initial inflammation to fibrosis capsule formation in detail and introduced various studies to overcome capsular contracture. Secondly, we introduced that the main research approaches are to inhibit fibrosis with anti-inflammatory drugs or antibiotics, to control the topography of the surface of silicone implants, and to administer plasma treatment. Each study examined aspects of the various mechanisms by which capsular contracture could occur, and addressed the effects of inhibiting fibrosis.

Conclusion: This review introduces various silicone surface modification methods to date and examines their limitations. This review will help identify new directions in inhibiting the fibrosis of silicone implants.

Keywords: Capsular contracture; Fibrosis; Foreign body reaction; Inflammation; Modification; Silicone implant.

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Conflict of interest statement

Not applicableNot applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Overview of different PDMS breast implant surface modifications. a SEM images and scheme of PDMS breast implants with smooth, microtextured, and textured surface morphology. The scale bar is 100 μm. The schematic depicts (b) antibacterial mesh, (c) antiadhesion barrier solution (AABS), (d) oxygen plasma modification to change hydrophobicity to hydrophilicity, and (e) antifibrosis drugs coated on the PDMS breast implant surface
See this image and copyright information in PMC

References

    1. Champaneria MC, Wong WW, Hill ME, Gupta SC. The evolution of breast reconstruction: a historical perspective. World J Surg. 2012;36(4):730–742. doi: 10.1007/s00268-012-1450-2. - DOI - PubMed
    1. Malahias M, Jordan D, Hughes L, Hindocha S, Juma A. A literature review and summary of capsular contracture: An ongoing challenge to breast surgeons and their patients. International Journal of Surgery Open. 2016;3:1–7. doi: 10.1016/j.ijso.2016.04.001. - DOI
    1. Headon H, Kasem A, Mokbel K. Capsular contracture after breast augmentation: an update for clinical practice. Archives of plastic surgery. 2015;42(5):532. doi: 10.5999/aps.2015.42.5.532. - DOI - PMC - PubMed
    1. Anderson JM, Rodriguez A, Chang DT. Foreign body reaction to biomaterials. Semin Immunol. 2008; Elsevier. - PMC - PubMed
    1. Cronin TD. Augmentation mammaplasty: a new" natural feel" prosthesis. Transact, III Internat Congr Plast Surg. 1964.