[Animal experimental models of breast cancer for therapeutic testing of hormones and antihormones]

Abstract

Syngeneically and xenogeneically transplanted hormone-dependent mammary carcinomas were used for therapeutic in vivo estimation of the effect of hormones and antihormones. During the transplantation the majority of the tumors of the rat shows development from hormone dependence to hormone independence and, consequently, chemically induced (DMBA, NMU) mammary carcinomas have been the subject of considerable interest. Hormone-dependent mammary carcinomas of the mouse (MXT, estradiol- and progesterone-induced tumors and pregnancy-dependent mammary tumors of different mouse strains) are suitable for estimation of the effects of hormones. Xenogeneically transplanted hormone-dependent human tumors (B0 or T61, Br-10, SE, MCF-7, ZR75-1) are introduced in testing of hormones. During the transplantation of human mammary carcinomas in nude mice the hormone receptor status is preserved, and it is possible to perform endocrine treatments in models of human mammary carcinomas.