Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar;13(2):113-124.
doi: 10.1007/s12072-018-9912-8. Epub 2019 Jan 2.

Immunological cure of HBV infection

Julia Lang  1 , Christoph Neumann-Haefelin  1 , Robert Thimme  2
Affiliations
Review

Immunological cure of HBV infection

Julia Lang et al. Hepatol Int. 2019 Mar.

Abstract

Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeutic strategies. Based on the current evidence on immunology in resolving and persistent HBV infection, we will review the growing field of immunotherapeutic approaches for treatment of chronic HBV infection. We will also discuss the challenge of a heterogeneous patient population and personalized treatment as a possible key factor of success.

Keywords: Adaptive immunity; CD4+ T-lymphocytes; CD8+ T-lymphocytes; Hepatitis B; Immunotherapy.

PubMed Disclaimer

References

    1. Science. 1999 Apr 30;284(5415):825-9 - PubMed
    1. Gastroenterology. 1999 Dec;117(6):1386-96 - PubMed
    1. J Virol. 2001 Sep;75(18):8781-91 - PubMed
    1. J Virol. 2003 Jan;77(1):68-76 - PubMed
    1. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6669-74 - PubMed

MeSH terms

Substances

LinkOut - more resources