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Clinical Trial
. 2020 Jan;42(1):69-73.
doi: 10.1097/MPH.0000000000001389.

Prevalence and Outcome of HIV-associated Malignancies Among HIV-infected Children Enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: A Hospital-based Retrospective Analytical Study

Michael Irira  1   2 , James S Ngocho  1   2 , Joshua Youze  1 , Irene Shayo  1 , Venancia Komba  1 , Linda Minja  3 , Francis P Karia  1   2 , John Bartlett  2   4 , Blandina T Mmbaga  1   2   3   4
Affiliations
Clinical Trial

Prevalence and Outcome of HIV-associated Malignancies Among HIV-infected Children Enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: A Hospital-based Retrospective Analytical Study

Michael Irira et al. J Pediatr Hematol Oncol. 2020 Jan.

Abstract

Objective: We aimed to establish the prevalence of human immunodeficiency virus (HIV)-associated malignancies in children attending a care and treatment clinic at Kilimanjaro Christian Medical Centre.

Materials and methods: This was a retrospective cross-sectional hospital-based study of children who attended an HIV care and treatment clinic between 2006 and 2014. Children 2 months to 17 years of age were eligible for participation. The data on social demographic and clinical characteristics were extracted from the medical record. A multivariate logistic regression model was developed to determine predictors of HIV-associated malignancies.

Results: Medical records from 721 HIV-infected children were reviewed. The median age (interquartile range) at HIV diagnosis was 5.7 (2.0 to 9.4) years. Among them, 34 (4.7%) had HIV-associated malignancies. The most common (n=24, 70.3%) malignancy was the Kaposi sarcoma. Age at HIV diagnosis was significantly associated with HIV-associated malignancies (adjusted odds ratio, 1.2; 95% confidence interval, 1.0-1.3). Among 34 patients with HIV-associated malignancies, 11 (32.4%) died. Seven (20.6%) patients reported complete remission from their malignancies, and outcomes for 6 patients were unknown.

Conclusions: The prevalence of HIV-associated malignancies was high and was associated with late HIV diagnosis. The Kaposi sarcoma was the commonest malignancy. Early HIV diagnosis and treatment in children might reduce HIV-associated malignancies.

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Conflict of interest statement

Conflict of interest

The authors declare that there is no conflict of interest for this work.

References

    1. United Nations Joint Programme on HIV/AIDS. Children and HIV. Vol. 296, Media; Geneva; 2016. Accessed June 2017
    1. United Nations Join Programme on HIV/AIDS. Country factsheets. United Republic of Tanzania; | 2016. Accessed June 2017.
    1. United Nations Joint Programme on HIV/AIDS. Regional Hiv Statistics — 2016. Accessed December 2017.
    1. Tukei VJ, Kekitiinwa A, Beasley RP. Prevalence and outcome of HIV-associated malignancies among children. AIDS. 2011. September 10;25(14):1789–93. - PubMed
    1. Chiappini E, Berti E, Gianesin K, Petrara MR, Galli L, Giaquinto C, et al. Pediatric Human Immunodeficiency Virus infection and cancer in the Highly Active Antiretroviral Treatment (HAART) era. Cancer Lett. Elsevier Ireland Ltd; 2014. May;347(1):38–45. - PubMed

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