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Comment
. 2019 Jan 3;380(1):94-96.
doi: 10.1056/NEJMcibr1811639.

Revealing the Secrets of Idiopathic Pulmonary Fibrosis

Richard K Albert  1 , David A Schwartz  1
Affiliations
Comment

Revealing the Secrets of Idiopathic Pulmonary Fibrosis

Richard K Albert et al. N Engl J Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
IPF is a heterogeneous disease, caused by abnormalities in host defense, bronchoalveolar cell function, cell senescence, and lung repair, all of which are affected by genetic variants, environmental exposures, and autoimmunity. While each of these biological processes can fail substantially and result in unique types of lung fibrosis (ChILD, RA-ILD, chronic HP, dyskeratosis congenital, or idiopathic pleuroparenchymal fibroelastosis), it is likely that most cases of IPF occur in those with mild to modest defects in one or several of these key mechanisms of lung homeostasis.
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References

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