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. 2019 Jan 2;14(1):e0207906.
doi: 10.1371/journal.pone.0207906. eCollection 2019.

Construct validity of acute morbidity as a novel outcome for emergency patients

Fabrizia Schmid  1 , Alexandra Malinovska  2 , Karin Weigel  3 , Tito Bosia  1 , Christian H Nickel  1 , Roland Bingisser  1
Affiliations

Construct validity of acute morbidity as a novel outcome for emergency patients

Fabrizia Schmid et al. PLoS One. .

Abstract

Objectives: Validation of acute morbidity as a novel outcome in emergency medicine.

Methods: Construct validity of acute morbidity was established by comparison to other outcomes using linear and logistic regression models.

Results: Data of 4608 patients were analysed. 1869 patients (40.6%) fulfilled the criteria for acute morbidity. Using multivariate analyses, acute morbidity was associated with outcomes such as hospitalisation (OR: 11, 95%-CI 9-13), mortality (OR 15, 95%-CI 6-49), and ICU admission (OR: 46, 95%-CI 25-96). Reliability of the construct "acute morbidity" was estimated using Cohens Kappa, which was 0.96 for intra-rater and 0.94 for inter-rater reliability.

Conclusion: Reliability of the framework for acute morbidity was high. Construct validity was shown by associations with hospitalisation, mortality, and ICU admission.

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Conflict of interest statement

Roland Bingisser is editor, Christian H. Nickel is co-editor of medstandards.com, a symptom-based decision-support tool licensed to 150 European hospitals, owned by the University Hospital of Basel. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

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Fig 1. Flow diagram of enrolment.
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